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- Title
Self-Oxygenation of Tissues Orchestrates Full-Thickness Vascularization of Living Implants.
- Authors
Farzin, Ali; Hassan, Shabir; Moreira Teixeira, Liliana S.; Gurian, Melvin; Crispim, João F.; Manhas, Varun; Carlier, Aurélie; Bae, Hojae; Geris, Liesbet; Noshadi, Iman; Shin, Su Ryon; Leijten, Jeroen
- Abstract
Bioengineering oftissues and organs has the potential to generate functional replacement organs. However, achieving the full-thickness vascularization that is required for long-term survival of living implants has remained a grand challenge, especially for clinically sized implants. During the pre-vascular phase, implanted engineered tissues are forced to metabolically rely on the diffusion of nutrients from adjacent host-tissue, which for larger living implants results in anoxia, cell death, and ultimately implant failure. Here it is reported that this challenge can be addressed by engineering self-oxygenating tissues, which is achieved via the incorporation of hydrophobic oxygen-generating micromaterials into engineered tissues. Self-oxygenation of tissues transforms anoxic stresses into hypoxic stimulation in a homogenous and tissue size-independent manner. The in situ elevation of oxygen tension enables the sustained production of high quantities of angiogenic factors by implanted cells, which are offered a metabolically protected proangiogenic microenvironment. Numerical simulations predict that self-oxygenation of living tissues will effectively orchestrate rapid full-thickness vascularization of implanted tissues, which is empirically confirmed via in vivo experimentation. Self-oxygenation of tissues thus represents a novel, effective, and widely applicable strategy to enable the vascularization living implants, which is expected to advance organ transplantation and regenerative medicine applications.
- Subjects
NEOVASCULARIZATION; CALCIUM; METABOLISM; PEROXIDES; OXYGEN
- Publication
Advanced Functional Materials, 2021, Vol 31, Issue 42, p1
- ISSN
1616-301X
- Publication type
Article
- DOI
10.1002/adfm.202100850