We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Bioorthogonal Strategies for Engineering Extracellular Matrices.
- Authors
Madl, Christopher M.; Heilshorn, Sarah C.
- Abstract
Abstract: Hydrogels are commonly used as engineered extracellular matrix (ECM) mimics in applications ranging from tissue engineering to in vitro disease models. Ideal mechanisms used to crosslink ECM‐mimicking hydrogels do not interfere with the biology of the system. However, most common hydrogel crosslinking chemistries exhibit some form of crossreactivity. The field of bioorthogonal chemistry has arisen to address the need for highly specific and robust reactions in biological contexts. Accordingly, bioorthogonal crosslinking strategies are incorporated into hydrogel design, allowing for gentle and efficient encapsulation of cells in various hydrogel materials. Furthermore, the selective nature of bioorthogonal chemistries can permit dynamic modification of hydrogel materials in the presence of live cells and other biomolecules to alter matrix mechanical properties and biochemistry on demand. This review provides an overview of bioorthogonal strategies used to prepare cell‐encapsulating hydrogels and highlights the potential applications of bioorthogonal chemistries in the design of dynamic engineered ECMs.
- Subjects
HYDROGELS; EXTRACELLULAR matrix; TISSUE engineering; CROSSLINKING (Polymerization); BIOMOLECULES
- Publication
Advanced Functional Materials, 2018, Vol 28, Issue 11, p1
- ISSN
1616-301X
- Publication type
Article
- DOI
10.1002/adfm.201706046