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- Title
d-Galactose toxicity in mice is associated with mitochondrial dysfunction: protecting effects of mitochondrial nutrient R-alpha-lipoic acid.
- Authors
Long, Jiangang; Wang, Xuemin; Gao, Hongxiang; Liu, Zhi; Liu, Changsheng; Miao, Mingyong; Cui, Xu; Packer, Lester; Liu, Jiankang
- Abstract
d-Galactose ( d-gal) -induced aging models in Drosophila, houseflies, mice and rats have been widely used; however, the underlying mechanisms are poorly understood. To investigate the involvement of mitochondrial dysfunction of d-gal, mitochondrial function was examined in the brain and liver of C57BL/6J mice, subjected to a treatment of d-gal with or without a concomitant treatment with a mitochondrial nutrient, R-alpha-lipoic acid (LA). d-Gal treatment induced a significant decrease in succinate-linked respiratory control ratio (RCR) and ADP/O ratio in the liver and brain, and also a significant increase in the maximum velocity (Vmax) and substrate binding affinity (Km) of complex II in the liver. LA treatment to d-gal-injected animals restored mitochondrial RCR in both brain and liver, ADP/O and Km of complex II in the liver. These results suggest LA is effective in delaying d-gal toxicity by ameliorating mitochondrial dysfunction.
- Publication
Biogerontology, 2007, Vol 8, Issue 3, p373
- ISSN
1389-5729
- Publication type
Article
- DOI
10.1007/s10522-007-9081-y