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- Title
Silent cerebral infarction in patients with type 2 diabetic nephropathy. Effects of antiplatelet drug dilazep dihydrochloride.
- Authors
Nakamura, Tsukasa; Kawagoe, Yasuhiro; Matsuda, Takaharu; Ueda, Yoshihiko; Ebihara, Isao; Koide, Hikaru
- Abstract
Background To determine whether diabetic nephropathy is a risk factor for silent cerebral infarction and whether antiplatelet drug dilazep dihydrochloride decreases the occurrence of silent cerebral infarction in type 2 diabetes patients with microalbuminuria. Methods Two hundred four type 2 diabetes patients (124 men, 80 women; age, median 56 years, range 42-74 years) and 60 healthy age-matched subjects (no diabetes, normal renal function) were recruited for brain magnetic resonance imaging. The diabetes patients included 40 without nephropathy (group A), 42 with microalbuminuria (20-200 µg/min) (group B), 44 with macroalbuminuria (>200 µg/min) and normal renal function (blood creatinine <132.7 µmol/L) (group C), 33 with chronic renal failure but not undergoing haemodialysis (blood creatinine >132.7 µmol/L; mean creatinine 335.9 µmol/L) (group D) and 45 undergoing haemodialysis (duration; median 4 years, range 3-6 years) (group E). Results Silent cerebral infarction was found in 20, 29, 34, 45, 53 and 8% of group A, B, C, D, E and control patients respectively. The incidence of silent cerebral infarction was increased with diabetic nephropathy. Thirty group B patients with no silent cerebral infarction were divided into two groups: (B1) 15 treated with dilazep dihydrochloride and (B2) 15 not treated with dilazep dihydrochloride. Treatment continued for 24 months. The incidence of silent cerebral infarction was significantly lower in the dilazep-treated patients (6.7%) than in the untreated patients (33.3%) ( p < 0.01). Conclusions These data suggest that diabetic renal dysfunction increases the risk of silent cerebral infarction and that dilazep dihydrochloride prevents its onset in early type 2 diabetic nephropathy patients. Copyright © 2004 John Wiley & Sons, Ltd.
- Publication
Diabetes/Metabolism Research & Reviews, 2005, Vol 21, Issue 1, p39
- ISSN
1520-7552
- Publication type
Article
- DOI
10.1002/dmrr.473