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- Title
Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island.
- Authors
Viala, Jérôme; Chaput, Catherine; Boneca, Ivo G.; Cardona, Ana; Girardin, Stephen E.; Moran, Anthony P.; Athman, Rafika; Mémet, Sylvie; Huerre, Michel R.; Coyle, Anthony J.; Distefano, Peter S.; Sansonetti, Philippe J.; Labigne, Agnès; Bertin, John; Philpott, Dana J.; Ferrero, Richard L.
- Abstract
Epithelial cells can respond to conserved bacterial products that are internalized after either bacterial invasion or liposome treatment of cells. We report here that the noninvasive Gram-negative pathogen Helicobacter pylori was recognized by epithelial cells via Nod1, an intracellular pathogen-recognition molecule with specificity for Gram-negative peptidoglycan. Nod1 detection of H. pylori depended on the delivery of peptidoglycan to host cells by a bacterial type IV secretion system, encoded by the H. pylori cag pathogenicity island. Consistent with involvement of Nod1 in host defense, Nod1-deficient mice were more susceptible to infection by cag pathogenicity island-positive H. pylori than were wild-type mice. We propose that sensing of H. pylori by Nod1 represents a model for host recognition of noninvasive pathogens.
- Subjects
PEPTIDOGLYCANS; HELICOBACTER pylori; EPITHELIAL cells; MICROBIAL polysaccharides; LIPOSOMES; PATHOGENIC microorganisms
- Publication
Nature Immunology, 2004, Vol 5, Issue 11, p1166
- ISSN
1529-2908
- Publication type
Article
- DOI
10.1038/ni1131