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- Title
Sonic hedgehog signal pathway has changed in testicular cancer.
- Authors
ONALAN, Ebru; BURAN, Ilay; TEKTEMUR, Ahmet; ÇALIK, Ilknur; DANIS, Nefsun
- Abstract
Testicular cancer is the most common malignancy, especially in men aged 15-35 years. Testicular tumors are classified as germ cell (seminoma, embryonal carcinoma, yolk sac, chiocarcinoma, teratoma, mix), sex cord stromal cell (leydig, sertoli, granulosa, monomafibroma) and various (lymphoma, leukemia, sarcoma, leomyoma, neurofibroma) (Voyvoda et al. 2017). Although the etiology of testicular tumors is not fully understood, genetic alterations have been identified in patients with testicular cancer (Albers et al. 2008). Recent studies have shown that the sonic hedgehog (SHH) signaling pathway, which has mitogenic and morphogenic functions, plays an important role in male genital system development (Haraguchi et al.2001). However, there is insufficient information about the expression of pathway and pathway related genes. In the current study, we aimed to evaluate the expression of SHH, GLI1,2,3,4, SMO, PTCH1,2 and STK36 genes. In our study, testicular tissue samples were obtained from 29 testicular cancer patients and 16 healthy individuals who applied to Firat University Hospital. According to histological types, samples were divided into 5 groups; control, seminoma, embryonal carcinoma, leomyoma and sex-cord stromal cell. The expression of GLI1,2,3,4, SMO, SHH, PTCH1,2 and STK36 genes was evaluated by qRT-PCR. In conclusion, analysis revealed a significant increase in expression of the SHH gene in all groups compared to the control. The data obtained show that the SHH gene plays an important role in the pathophysiology of testicular cancer and strategies that target the gene can be used to treat the disease.
- Subjects
TESTICULAR cancer; MALE reproductive organ cancer; CYTOKINES; GENE expression; OXIDATIVE stress
- Publication
Journal of Cellular Neuroscience & Oxidative Stress, 2018, Vol 10, Issue 2, p761
- ISSN
2149-7222
- Publication type
Article