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- Title
BAG-1 in carcinogenesis.
- Authors
Sharp, Adam; Crabb, Simon J.; Cutress, Ramsey I.; Brimmell, Matthew; Wang, Xiu-hong; Packham, Graham; Townsend, Paul A.
- Abstract
BAG-1 is a multifunctional protein that exists as several differentially localised and functionally distinct isoforms. BAG-1 isoforms interact with a diverse array of molecular targets and regulate a wide range of cellular processes, including proliferation, survival, transcription, apoptosis, metastasis and motility. The BAG domain of BAG-1 interacts with chaperone molecules and this is considered important for many BAG-1 functions. The ability of BAG-1 to regulate such a wide variety of cellular processes suggests it might play an important role in many cancer types. For example, regulation of nuclear hormone receptor function and susceptibility to apoptosis might have a major impact on cancer development, progression and response to therapy. There is also increasing evidence that BAG-1 expression is altered in a variety of human malignancies relative to normal cells, and with further understanding of BAG-1 function it might become a powerful prognostic/predictive marker in human cancer. This review describes the structure and function of BAG-1 isoforms and the potential clinical implications of their expression in tumour cells.
- Publication
Expert Reviews in Molecular Medicine, 2004, Vol 6, Issue 7, p1
- ISSN
1462-3994
- Publication type
Article
- DOI
10.1017/S1462399404007537