OpenURL Connection Search

Select item for more details and to access through your institution.

NAADP induces Ca2+ oscillations via a two-pool mechanism by priming IP3- and cADPR-sensitive Ca2+ stores.
Published in:
EMBO Journal, 2001, v. 20, n. 11, p. 2666, doi. 10.1093/emboj/20.11.2666
By:
- Churchill, Grant C.;
- Galione, Antony
Publication type:
Article
Adenosine integrates light and sleep signalling for the regulation of circadian timing in mice.
Published in:
Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-22179-z
By:
- Jagannath, Aarti;
- Varga, Norbert;
- Dallmann, Robert;
- Rando, Gianpaolo;
- Gosselin, Pauline;
- Ebrahimjee, Farid;
- Taylor, Lewis;
- Mosneagu, Dragos;
- Stefaniak, Jakub;
- Walsh, Steven;
- Palumaa, Teele;
- Di Pretoro, Simona;
- Sanghani, Harshmeena;
- Wakaf, Zeinab;
- Churchill, Grant C.;
- Galione, Antony;
- Peirson, Stuart N.;
- Boison, Detlev;
- Brown, Steven A.;
- Foster, Russell G.
Publication type:
Article
Examination of betahistine bioavailability in combination with the monoamine oxidase B inhibitor, selegiline, in humans--a non-randomized, single-sequence, two-period titration, open label single-center phase 1 study (PK-BeST).
Published in:
Frontiers in Neurology, 2023, p. 01, doi. 10.3389/fneur.2023.1271640
By:
- Strupp, Michael;
- Churchill, Grant C.;
- Naumann, Ivonne;
- Mansmann, Ulrich;
- Al Tawil, Amani;
- Golentsova, Anastasia;
- Goldschagg, Nicolina
Publication type:
Article
Fluorescent Copper(II) Bis(thiosemicarbazonates): Synthesis, Structures, Electron Paramagnetic Resonance, Radiolabeling, In Vitro Cytotoxicity and Confocal Fluorescence Microscopy Studies.
Published in:
Chemistry - An Asian Journal, 2010, v. 5, n. 3, p. 506, doi. 10.1002/asia.200900446
By:
- Pascu, Sofia I.;
- Waghorn, Philip A.;
- Kennedy, Brett W. C.;
- Arrowsmith, Rory L.;
- Bayly, Simon R.;
- Dilworth, Jonathan R.;
- Christlieb, Martin;
- Tyrrell, Rex M.;
- Zhong, Julia;
- Kowalczyk, Radoslaw M.;
- Collison, David;
- Aley, Parvinder K.;
- Churchill, Grant C.;
- Aigbirhio, Franklin I.
Publication type:
Article
Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium.
Published in:
Nature Medicine, 2008, v. 14, n. 11, p. 1247, doi. 10.1038/nm.1876
By:
- Lloyd-Evans, Emyr;
- Morgan, Anthony J.;
- Xingxuan He;
- Smith, David A.;
- Elliot-Smith, Elena;
- Sillence, Daniel J.;
- Churchill, Grant C.;
- Schuchman, Edward H.;
- Galione, Antony;
- Platt, Frances M.
Publication type:
Article
Calcium signalling by nicotinic acid adenine dinucleotide phosphate (NAADP).
Published in:
FEBS Journal, 2005, v. 272, n. 18, p. 4598, doi. 10.1111/j.1742-4658.2005.04860.x
By:
- Yamasaki, Michiko;
- Churchill, Grant C.;
- Galione, Antony
Publication type:
Article
Discovery of Novel GPVI Receptor Antagonists by Structure-Based Repurposing.
Published in:
PLoS ONE, 2014, v. 9, n. 6, p. 1, doi. 10.1371/journal.pone.0101209
By:
- Taylor, Lewis;
- Vasudevan, Sridhar R.;
- Jones, Chris I.;
- Gibbins, Jonathan M.;
- Churchill, Grant C.;
- Campbell, R. Duncan;
- Coxon, Carmen H.
Publication type:
Article
Scaffold Hopping with Virtual Screening from IP3 to a Drug-Like Partial Agonist of the Inositol Trisphosphate Receptor.
Published in:
ChemBioChem, 2014, v. 15, n. 18, p. 2774, doi. 10.1002/cbic.201402440
By:
- Vasudevan, Sridhar R.;
- Singh, Nisha;
- Churchill, Grant C.
Publication type:
Article
Defective platelet function in Niemann‐Pick disease type C1.
Published in:
Journal of Inherited Metabolic Disease Reports, 2020, v. 56, n. 1, p. 46, doi. 10.1002/jmd2.12148
By:
- Chen, Oscar C. W.;
- Colaco, Alexandria;
- Davis, Lianne C.;
- Kiskin, Fedir N.;
- Farhat, Nicole Y.;
- Speak, Anneliese O.;
- Smith, David A.;
- Morris, Lauren;
- Eden, Emily;
- Tynan, Patricia;
- Churchill, Grant C.;
- Galione, Antony;
- Porter, Forbes D.;
- Platt, Frances M.
Publication type:
Article
Unexpected differences in the pharmacokinetics of N-acetyl-DL-leucine enantiomers after oral dosing and their clinical relevance.
Published in:
PLoS ONE, 2020, v. 15, n. 2, p. 1, doi. 10.1371/journal.pone.0229585
By:
- Churchill, Grant C.;
- Strupp, Michael;
- Galione, Antony;
- Platt, Frances M.
Publication type:
Article
A safe lithium mimetic for bipolar disorder.
Published in:
Nature Communications, 2013, v. 4, n. 1, p. 1332, doi. 10.1038/ncomms2320
By:
- Singh, Nisha;
- Halliday, Amy C.;
- Thomas, Justyn M.;
- Kuznetsova, Olga V.;
- Baldwin, Rhiannon;
- Woon, Esther C. Y.;
- Aley, Parvinder K.;
- Antoniadou, Ivi;
- Sharp, Trevor;
- Vasudevan, Sridhar R.;
- Churchill, Grant C.
Publication type:
Article
Acetylation turns leucine into a drug by membrane transporter switching.
Published in:
Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-95255-5
By:
- Churchill, Grant C.;
- Strupp, Michael;
- Factor, Cailley;
- Bremova-Ertl, Tatiana;
- Factor, Mallory;
- Patterson, Marc C.;
- Platt, Frances M.;
- Galione, Antony
Publication type:
Article
Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP.
Published in:
Human Molecular Genetics, 2012, v. 21, n. 3, p. 511, doi. 10.1093/hmg/ddr481
By:
- Gómez-Suaga, Patricia;
- Luzón-Toro, Berta;
- Churamani, Dev;
- Zhang, Ling;
- Bloor-Young, Duncan;
- Patel, Sandip;
- Woodman, Philip G.;
- Churchill, Grant C.;
- Hilfiker, Sabine
Publication type:
Article
Iron-induced cytotoxicity mediated by endolysosomal TRPML1 channels is reverted by TFEB.
Published in:
Cell Death & Disease, 2022, v. 13, n. 12, p. 1, doi. 10.1038/s41419-022-05504-2
By:
- Fernández, Belén;
- Olmedo, Pablo;
- Gil, Fernando;
- Fdez, Elena;
- Naaldijk, Yahaira;
- Rivero-Ríos, Pilar;
- Bracher, Franz;
- Grimm, Christian;
- Churchill, Grant C.;
- Hilfiker, Sabine
Publication type:
Article
A link between LRRK2, autophagy and NAADP-mediated endolysosomal calcium signallinga.
Published in:
Biochemical Society Transactions, 2012, v. 40, n. 5, p. 1140, doi. 10.1042/BST20120138
By:
- Gómez-Suaga, Patricia;
- Churchill, Grant C.;
- Patel, Sandip;
- Hilfiker, Sabine
Publication type:
Article
NAADP mediates ATP-induced Ca2+ signals in astrocytes
Published in:
FEBS Letters, 2011, v. 585, n. 14, p. 2300, doi. 10.1016/j.febslet.2011.05.062
By:
- Barceló-Torns, Miquel;
- Lewis, Alexander M.;
- Gubern, Albert;
- Barneda, David;
- Bloor-Young, Duncan;
- Picatoste, Fernado;
- Churchill, Grant C.;
- Claro, Enrique;
- Masgrau, Roser
Publication type:
Article
Identification of a chemical probe for NAADP by virtual screening.
Published in:
Nature Chemical Biology, 2009, v. 5, n. 4, p. 220, doi. 10.1038/nchembio.150
By:
- Naylor, Edmund;
- Arredouani, Abdelilah;
- Vasudevan, Sridhar R.;
- Lewis, Alexander M.;
- Parkesh, Raman;
- Mizote, Akiko;
- Rosen, Daniel;
- Thomas, Justyn M.;
- Izumi, Minoru;
- Ganesan, A.;
- Galione, Antony;
- Churchill, Grant C.
Publication type:
Article
Coordination of agonist-induced Ca2+-signalling patterns by NAADP in pancreatic acinar cells.
Published in:
Nature, 1999, v. 398, n. 6722, p. 74, doi. 10.1038/18032
By:
- Cancela, Jose Manuel;
- Churchill, Grant C.;
- Galione, Antony
Publication type:
Article
Plasma glutathione suggests oxidative stress is equally present in early‐ and late‐onset bipolar disorder.
Published in:
Bipolar Disorders, 2019, v. 21, n. 1, p. 61, doi. 10.1111/bdi.12640
By:
- Singh, Nisha;
- McMahon, Hannah;
- Bilderbeck, Amy;
- Reed, Zoe E;
- Tunbridge, Elizabeth;
- Brett, Daniel;
- Geddes, John R;
- Churchill, Grant C;
- Goodwin, Guy M
Publication type:
Article
The putative lithium-mimetic ebselen reduces impulsivity in rodent models.
Published in:
2018
By:
- Barkus, Chris;
- Ferland, Jacqueline-Marie N.;
- Adams, Wendy K.;
- Churchill, Grant C.;
- Cowen, Philip J.;
- Bannerman, David M.;
- Rogers, Robert D.;
- Winstanley, Catharine A.;
- Sharp, Trevor
Publication type:
journal article

Found: 20

NAADP induces Ca<sup>2+</sup> oscillations via a two-pool mechanism by priming IP<sub>3</sub>- and cADPR-sensitive Ca<sup>2+</sup> stores.

Adenosine integrates light and sleep signalling for the regulation of circadian timing in mice.

Examination of betahistine bioavailability in combination with the monoamine oxidase B inhibitor, selegiline, in humans--a non-randomized, single-sequence, two-period titration, open label single-center phase 1 study (PK-BeST).

Fluorescent Copper(II) Bis(thiosemicarbazonates): Synthesis, Structures, Electron Paramagnetic Resonance, Radiolabeling, In Vitro Cytotoxicity and Confocal Fluorescence Microscopy Studies.

Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium.

Calcium signalling by nicotinic acid adenine dinucleotide phosphate (NAADP).

Discovery of Novel GPVI Receptor Antagonists by Structure-Based Repurposing.

Scaffold Hopping with Virtual Screening from IP<sub>3</sub> to a Drug-Like Partial Agonist of the Inositol Trisphosphate Receptor.

Defective platelet function in Niemann‐Pick disease type C1.

Unexpected differences in the pharmacokinetics of N-acetyl-DL-leucine enantiomers after oral dosing and their clinical relevance.

A safe lithium mimetic for bipolar disorder.

Acetylation turns leucine into a drug by membrane transporter switching.

Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP.

Iron-induced cytotoxicity mediated by endolysosomal TRPML1 channels is reverted by TFEB.

A link between LRRK2, autophagy and NAADP-mediated endolysosomal calcium signallinga.

NAADP mediates ATP-induced Ca<sup>2+</sup> signals in astrocytes

Identification of a chemical probe for NAADP by virtual screening.

Coordination of agonist-induced Ca2+-signalling patterns by NAADP in pancreatic acinar cells.

Plasma glutathione suggests oxidative stress is equally present in early‐ and late‐onset bipolar disorder.

The putative lithium-mimetic ebselen reduces impulsivity in rodent models.