We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
The effects of meldonium on the acute ischemia/reperfusion liver injury in rats.
- Authors
Đurašević, Siniša; Stojković, Maja; Sopta, Jelena; Pavlović, Slađan; Borković-Mitić, Slavica; Ivanović, Anđelija; Jasnić, Nebojša; Tosti, Tomislav; Đurović, Saša; Đorđević, Jelena; Todorović, Zoran
- Abstract
Acute ischemia/reperfusion (I/R) liver injury is a clinical condition challenging to treat. Meldonium is an anti-ischemic agent that shifts energy production from fatty acid oxidation to less oxygen-consuming glycolysis. Thus, we investigated the effects of a 4-week meldonium pre-treatment (300 mg/kg b.m./day) on the acute I/R liver injury in Wistar strain male rats. Our results showed that meldonium ameliorates I/R-induced liver inflammation and injury, as confirmed by liver histology, and by attenuation of serum alanine- and aspartate aminotransferase activity, serum and liver high mobility group box 1 protein expression, and liver expression of Bax/Bcl2, haptoglobin, and the phosphorylated nuclear factor kappa-light-chain-enhancer of activated B cells. Through the increased hepatic activation of the nuclear factor erythroid 2-related factor 2, meldonium improves the antioxidative defence in the liver of animals subjected to I/R, as proved by an increase in serum and liver ascorbic/dehydroascorbic acid ratio, hepatic haem oxygenase 1 expression, glutathione and free thiol groups content, and hepatic copper-zinc superoxide dismutase, manganese superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase activity. Based on our results, it can be concluded that meldonium represent a protective agent against I/R-induced liver injury, with a clinical significance in surgical procedures.
- Subjects
LIVER injuries; FATTY acid oxidation; GLYCOLYSIS; BLOOD serum analysis; LABORATORY rats
- Publication
Scientific Reports, 2021, Vol 10, Issue 1, p1
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/s41598-020-80011-y