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- Title
A case of dysgraphia induced by sertraline and a review of official spontaneous adverse reaction databases.
- Authors
Gentili, M.; Marinaccio, P. M.; Galimberti, C.; Carnovale, C.; Antoniazzi, S.; Pozzi, M.; Clementi, E.; Viganò, C.; Radice, S.
- Abstract
What is known and objectives The occurrence of dysgraphia after sertraline intake has never been reported. The objective was to describe a case of this adverse drug reaction and present a review of similar cases held in international databases with a discussion of the possible pharmacological mechanisms. Case summary We observed a 60-year-old man who experienced resting tremors, dyskinesia and dysgraphia 2 months after a stepwise increase in sertraline dosing from 50 to 200 mg/day. What is new and conclusion Dysgraphia is a possible adverse drug reaction to sertraline, and we suggest that inhibition of extrapyramidal dopaminergic activity might be the pharmacological mechanism.
- Subjects
ANTIDEPRESSANTS; MENTAL depression; BIBLIOGRAPHIC databases; BIPOLAR disorder; AGRAPHIA; BASAL ganglia diseases; DRUG side effects; CASE studies; MEDICAL informatics; PHARMACOLOGY; RESEARCH funding; SERTRALINE; TARDIVE dyskinesia; TREMOR; PHARMACODYNAMICS; DIAGNOSIS; PSYCHOLOGY
- Publication
Journal of Clinical Pharmacy & Therapeutics, 2016, Vol 41, Issue 1, p106
- ISSN
0269-4727
- Publication type
Article
- DOI
10.1111/jcpt.12356