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- Title
Antibiotic resistance rates of Pseudomonas aeruginosa, Acinetobacter baumannii and Klebsiella pneumoniae isolated from a university-affiliated hospital in North Cyprus.
- Authors
RUH, Emrah; GAZİ, Umut; GÜVENİR, Meryem; SÜER, Kaya; ÇAKIR, Nedim
- Abstract
Objective: Infections caused by resistant gramnegative bacteria to antimicrobials occur at increasing rates. Therefore, routine screening of resistance patterns is crucial for treatment approaches using proper antibiotics. Nevertheless, there is not enough data with respect to antibiotic resistance profiles in North Cyprus. This study was conducted in order to investigate the resistance rates of Pseudomonas aeruginosa, Acinetobacter baumannii and Klebsiella pneumoniae which were isolated from the Near East University (NEU) Hospital, North Cyprus. Method: It was included in this study P. aeruginosa, A. baumannii and K. pneumoniae which were isolated in the NEU Hospital Clinical Microbiology Laboratory between 01 August 2010 and 31 December 2014. Identification and susceptibility tests were performed by using the BD Phoenix 100 system (software version 6.01A). The antimicrobial susceptibility test results were determined according to the Clinical and Laboratory Standards Institute (CLSI) guidelines, and the resistance rates of bacterial isolates to antibiotics were examined retrospectively. Results: It was evaluated that the antibiotic resistance rates of 186 P. aeruginosa, 61 A. baumannii, and 204 K. pneumoniae strains which were isolated between August 2010 and December 2014 at the NEU Hospital. P. aeruginosa isolates were mostly resistant to aztreonam (42.9%), ceftazidime (19.5%), levofloxacin (20.2%) and ciprofloxacin (18.8%). In contrary, resistance rates for imipenem and meropenem were lower (11.8% and 6.5%, respectively). A. baumannii displayed high resistance (32.8%-92.7%) to most of the antibiotics tested, while the resistance rate for colistin was 5.1%. The highest antimicrobial resistance rates in K. pneumoniae isolates were detected in ampicillinsulbactam (39.9%), cefazolin (35.3%), cefuroxime (34.2%) and tetracycline (30.8%); while the lowest rates of resistance were recorded for ertapenem (4.6%), imipenem (0.0%), meropenem (1.0%) and amikacin (0.0%). Besides, extended-spectrum beta-lactamase (ESBL) positive results were obtained among 16.7% of K. pneumoniae isolates. Conclusion: According to literature review, this is the first study that evaluated the antimicrobial resistance rates of P. aeruginosa, A. baumannii and K. pneumoniae isolates in a centre in North Cyprus. Among the antibiotics tested, particularly the carbapenem resistance in P. aeruginosa and K. pneumoniae strains, and colisitin resistance in A. baumannii were detected at lower rates in comparison to the other studies where high rates of resistance were documented. Nevertheless, the results of this study indicate that antibiotic resistance in our hospital cannot be ignored, and the test results should be monitored routinely. By conducting multi-centered studies, more comprehensive data on antimicrobial resistance patterns and the underlying genetic mechanisms should be documented in North Cyprus.
- Subjects
PSEUDOMONAS aeruginosa; ACINETOBACTER baumannii; KLEBSIELLA pneumoniae
- Publication
Turkish Bulletin of Hygiene & Experimental Biology / Türk Hijyen ve Deneysel Biyoloji, 2016, Vol 73, Issue 4, p333
- ISSN
0377-9777
- Publication type
Article
- DOI
10.5505/TurkHijyen.2016.82653