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Gestational choriocarcinoma: an unusual presentation with response to gemcitabine and surgery.
Published in:
BJOG: An International Journal of Obstetrics & Gynaecology, 2004, v. 111, n. 4, p. 382, doi. 10.1111/j.1471-0528.2004.00065x.x
By:
- Pandian, Zabeena;
- Seckl, Michael J.;
- Smith, Richard;
- Lees, D. A. Russell
Publication type:
Article
Retroperitoneal lymph node dissection after chemotherapy in patients with elevated tumour markers: indications, histopathology and outcome.
Published in:
BJU International, 2008, v. 102, n. 2, p. 198, doi. 10.1111/j.1464-410X.2008.07533.x
By:
- Ong, Teng A.;
- Winkler, Mathias H.;
- Savage, Philip M.;
- Seckl, Michael J.;
- Christmas, Timothy J.
Publication type:
Article
Repeat retroperitoneal lymph-node dissection after chemotherapy for metastatic testicular germ cell tumour.
Published in:
BJU International, 2007, v. 100, n. 4, p. 809, doi. 10.1111/j.1464-410X.2007.07087.x
By:
- Willis, Susan F.;
- Winkler, Mathias;
- Savage, Philip;
- Seckl, Michael J.;
- Christmas, Timothy J.
Publication type:
Article
S6K2: the neglected S6 kinase family member.
Published in:
Frontiers in Oncology, 2013, v. 3, p. 1, doi. 10.3389/fonc.2013.00191
By:
- Pardo, Olivier E.;
- Seckl, Michael J.
Publication type:
Article
Diagnosis and management of gestational trophoblastic disease: 2021 update.
Published in:
2021
By:
- Ngan, Hextan Y. S.;
- Seckl, Michael J.;
- Berkowitz, Ross S.;
- Xiang, Yang;
- Golfier, François;
- Sekharan, Paradan K.;
- Lurain, John R.;
- Massuger, Leon
Publication type:
journal article
Update on the diagnosis and management of gestational trophoblastic disease.
Published in:
2018
By:
- Ngan, Hextan Y S;
- Seckl, Michael J;
- Berkowitz, Ross S;
- Xiang, Yang;
- Golfier, François;
- Sekharan, Paradan K;
- Lurain, John R;
- Massuger, Leon
Publication type:
journal article
Gestational Trophoblastic Tumours: An Update for 2014.
Published in:
Current Oncology Reports, 2014, v. 16, n. 11, p. 1, doi. 10.1007/s11912-014-0408-y
By:
- Froeling, Fieke E. M.;
- Seckl, Michael J.
Publication type:
Article
FGF-2 protects small cell lung cancer cells from apoptosis through a complex involving PKCɛ, B-Raf and S6K2.
Published in:
EMBO Journal, 2006, v. 25, n. 13, p. 3078, doi. 10.1038/sj.emboj.7601198
By:
- Pardo, Olivier E.;
- Wellbrock, Claudia;
- Khanzada, Umme K.;
- Aubert, Muriel;
- Arozarena, Imanol;
- Davidson, Sally;
- Bowen, Frances;
- Parker, Peter J.;
- Filonenko, V. V.;
- Gout, Ivan T.;
- Sebire, Neil;
- Marais, Richard;
- Downward, Julian;
- Seckl, Michael J.
Publication type:
Article
Two distinct phosphoinositide 3-kinases mediate polypeptide growth factor-stimulated PKB activation.
Published in:
EMBO Journal, 2002, v. 21, n. 19, p. 5097, doi. 10.1093/emboj/cdf512
By:
- Arcaro, Alexandre;
- Khanzada, Umme K.;
- Vanhaesebroeck, Bart;
- Tetley, Teresa D.;
- Waterfield, Michael D.;
- Seckl, Michael J.
Publication type:
Article
Differential Expression of RSK4 Transcript Isoforms in Cancer and Its Clinical Relevance.
Published in:
International Journal of Molecular Sciences, 2022, v. 23, n. 23, p. 14569, doi. 10.3390/ijms232314569
By:
- Chen, Sisi;
- Seckl, Michael J.;
- Lorentzen, Marc P. G.;
- Pardo, Olivier E.
Publication type:
Article
From National to International Collaboration in Gestational Trophoblastic Disease: Hurdles and Possibilities.
Published in:
Gynecologic & Obstetric Investigation, 2024, v. 89, n. 3, p. 254, doi. 10.1159/000534321
By:
- Golfier, Francois;
- Seckl, Michael J.
Publication type:
Article
hnRNPA1 couples nuclear export and translation of specific mRNAs downstream of FGF-2/S6K2 signalling.
Published in:
Nucleic Acids Research, 2014, v. 42, n. 20, p. 12483, doi. 10.1093/nar/gku953
By:
- Roy, Rajat;
- Durie, Danielle;
- Li, Hui;
- Liu, Bing-Qian;
- Skehel, John Mark;
- Mauri, Francesco;
- Cuorvo, Lucia Veronica;
- Barbareschi, Mattia;
- Guo, Lin;
- Holcik, Martin;
- Seckl, Michael J.;
- Pardo, Olivier E.
Publication type:
Article
What is the optimal duration, dose and frequency for anti-PD1 therapy of non-small cell lung cancer?
Published in:
Therapeutic Advances in Medical Oncology, 2023, p. 1, doi. 10.1177/17588359231210271
By:
- Kuah, Chii Yang;
- Monfries, Robert;
- Quartagno, Matteo;
- Seckl, Michael J.;
- Ghorani, Ehsan
Publication type:
Article
Setting up non-commercial clinical trials takes too long in the UK: findings from a prospective study.
Published in:
Journal of the Royal Society of Medicine, 2008, v. 101, n. 6, p. 299, doi. 10.1258/jrsm.2008.070373
By:
- Hackshaw, Allan;
- Farrant, Hannah;
- Bulley, Sue;
- Seckl, Michael J.;
- Ledermann, Jonathan A.
Publication type:
Article
Nemo-like kinase regulates the expression of vascular endothelial growth factor (VEGF) in alveolar epithelial cells.
Published in:
Scientific Reports, 2016, p. 23987, doi. 10.1038/srep23987
By:
- Ke, Hengning;
- Masoumi, Katarzyna Chmielarska;
- Ahlqvist, Kristofer;
- Seckl, Michael J.;
- Rydell-Törmänen, Kristina;
- Massoumi, Ramin
Publication type:
Article
Glycogen Synthase Kinase 3 Protein Kinase Activity Is Frequently Elevated in Human Non-Small Cell Lung Carcinoma and Supports Tumour Cell Proliferation.
Published in:
PLoS ONE, 2014, v. 9, n. 12, p. 1, doi. 10.1371/journal.pone.0114725
By:
- Vincent, Emma E.;
- Elder, Douglas J. E.;
- O′Flaherty, Linda;
- Pardo, Olivier E.;
- Dzien, Piotr;
- Phillips, Lois;
- Morgan, Carys;
- Pawade, Joya;
- May, Margaret T.;
- Sohail, Muhammad;
- Hetzel, Martin R.;
- Seckl, Michael J.;
- Tavaré, Jeremy M.
Publication type:
Article
An Inflammation Based Score Can Optimize the Selection of Patients with Advanced Cancer Considered for Early Phase Clinical Trials.
Published in:
PLoS ONE, 2014, v. 9, n. 1, p. 1, doi. 10.1371/journal.pone.0083279
By:
- Pinato, David J.;
- Stavraka, Chara;
- Flynn, Michael J.;
- Forster, Martin D.;
- O'Cathail, Séan M.;
- Seckl, Michael J.;
- Kristeleit, Rebecca S.;
- Olmos, David;
- Turnbull, Samantha J.;
- Blagden, Sarah P.
Publication type:
Article
A Novel Requirement for Janus Kinases as Mediators of Drug Resistance Induced by Fibroblast Growth Factor-2 in Human Cancer Cells.
Published in:
PLoS ONE, 2011, v. 6, n. 5, p. 1, doi. 10.1371/journal.pone.0019861
By:
- Carmo, Catarina R.;
- Lyons-Lewis, Janet;
- Seckl, Michael J.;
- Costa-Pereira, Ana P.
Publication type:
Article
A Pictorial Ultrasound Essay of Gestational Trophoblastic Disease.
Published in:
Journal of Ultrasound in Medicine, 2020, v. 39, n. 3, p. 597, doi. 10.1002/jum.15119
By:
- Cavoretto, Paolo;
- Cioffi, Raffaella;
- Mangili, Giorgia;
- Petrone, Micaela;
- Bergamini, Alice;
- Rabaiotti, Emanuela;
- Valsecchi, Luca;
- Candiani, Massimo;
- Seckl, Michael J
Publication type:
Article
Update on the diagnosis and management of gestational trophoblastic disease.
Published in:
International Journal of Gynecology & Obstetrics, 2015, v. 131, p. S123, doi. 10.1016/j.ijgo.2015.06.008
By:
- Ngan, Hextan Y.S.;
- Seckl, Michael J.;
- Berkowitz, Ross S.;
- Xiang, Yang;
- Golfier, François;
- Sekharan, P.K.;
- Lurain, John R.
Publication type:
Article
Update on the diagnosis and management of gestational trophoblastic disease.
Published in:
2015
By:
- Ngan, Hextan Y S;
- Seckl, Michael J;
- Berkowitz, Ross S;
- Xiang, Yang;
- Golfier, François;
- Sekharan, P K;
- Lurain, John R
Publication type:
journal article
Corrigendum to “Trophoblastic disease” [Int J Gynecol Obstet 2012 119(Suppl. 2) S130–6].
Published in:
2014
By:
- Ngan, Hextan Y.S.;
- Kohorn, Ernest I.;
- Cole, Laurence A.;
- Kurman, Robert J.;
- Kim, Seung J.;
- Lurain, John R.;
- Seckl, Michael J.;
- Sasaki, Shigeru;
- Soper, John T.
Publication type:
Erratum
Trophoblastic disease
Published in:
International Journal of Gynecology & Obstetrics, 2012, v. 119, n. s2, p. S130, doi. 10.1016/S0020-7292(12)60026-5
By:
- Ngan, Hextan Y.S.;
- Kohorn, Ernest I.;
- Cole, Laurence A.;
- Kurman, Robert J.;
- Kim, Seung J.;
- Lurain, John R.;
- Seckl, Michael J.;
- Sasaki, Shigeru;
- Soper, John T.
Publication type:
Article
Abnormal villous morphology mimicking a hydatidiform mole associated with paternal trisomy of chromosomes 3,7,8 and unipaternal disomy of chromosome 11.
Published in:
2016
By:
- Sebire, Neil J.;
- May, Philippa C.;
- Kaur, Baljeet;
- Seckl, Michael J.;
- Fisher, Rosemary A.
Publication type:
Case Study
miR-515-5p controls cancer cell migration through MARK4 regulation.
Published in:
EMBO Reports, 2016, v. 17, n. 4, p. 570, doi. 10.15252/embr.201540970
By:
- Pardo, Olivier E;
- Castellano, Leandro;
- Munro, Catriona E;
- Hu, Yili;
- Mauri, Francesco;
- Krell, Jonathan;
- Lara, Romain;
- Pinho, Filipa G;
- Choudhury, Thameenah;
- Frampton, Adam E;
- Pellegrino, Loredana;
- Pshezhetskiy, Dmitry;
- Wang, Yulan;
- Waxman, Jonathan;
- Seckl, Michael J;
- Stebbing, Justin
Publication type:
Article
Sensitive screening of single nucleotide polymorphisms in cell free DNA for diagnosis of gestational tumours.
Published in:
NPJ Genomic Medicine, 2022, v. 7, n. 1, p. 1, doi. 10.1038/s41525-022-00297-x
By:
- Maher, Geoffrey J.;
- Fisher, Rosemary A.;
- Kaur, Baljeet;
- Aguiar, Xianne;
- Aravind, Preetha;
- Cedeno, Natashia;
- Clark, James;
- Damon, Debbie;
- Ghorani, Ehsan;
- Januszewski, Adam;
- Kalofonou, Foteini;
- Murphy, Ravindhi;
- Roy, Rajat;
- Sarwar, Naveed;
- Openshaw, Mark R.;
- Seckl, Michael J.
Publication type:
Article
Novel cross talk between MEK and S6K2 in FGF-2 induced proliferation of SCLC cells.
Published in:
Oncogene, 2001, v. 20, n. 52, p. 7658, doi. 10.1038/sj.onc.1204994
By:
- Pardo, Olivier E;
- Arcaro, Alexandre;
- Salerno, Giovanni;
- Tetley, Teresa D;
- Valovka, Taras;
- Gout, Ivan;
- Seckl, Michael J
Publication type:
Article
Immortalization of Human Alveolar Epithelial Cells to Investigate Nanoparticle Uptake.
Published in:
American Journal of Respiratory Cell & Molecular Biology, 2008, v. 39, n. 5, p. 591, doi. 10.1165/rcmb.2007-0334OC
By:
- Kemp, Sarah J.;
- Thorley, Andrew J.;
- Gorelik, Julia;
- Seckl, Michael J.;
- O'Hare, Michael J.;
- Arcaro, Alexandre;
- Korchev, Yuri;
- Goldstraw, Peter;
- Tetley, Teresa D.
Publication type:
Article
PREDICT‐GTN 1: Can we improve the FIGO scoring system in gestational trophoblastic neoplasia?
Published in:
International Journal of Cancer, 2023, v. 152, n. 5, p. 986, doi. 10.1002/ijc.34352
By:
- Parker, Victoria L.;
- Winter, Matthew C.;
- Tidy, John A.;
- Hancock, Barry W.;
- Palmer, Julia E.;
- Sarwar, Naveed;
- Kaur, Baljeet;
- McDonald, Katie;
- Aguiar, Xianne;
- Singh, Kamaljit;
- Unsworth, Nick;
- Jabbar, Imran;
- Pacey, Allan A.;
- Harrison, Robert F.;
- Seckl, Michael J.
Publication type:
Article
Acute lymphoblastic leukaemia relapsing in bowel.
Published in:
European Journal of Haematology, 1991, v. 47, n. 5, p. 377, doi. 10.1111/j.1600-0609.1991.tb01864.x
By:
- Seckl, Michael J.;
- Gregory, Monica M.;
- Watkins, Sylvia M.
Publication type:
Article
Intensified therapies improve survival and identification of novel prognostic factors for placental-site and epithelioid trophoblastic tumours.
Published in:
2019
By:
- Froeling, Fieke E. M.;
- Ramaswami, Ramya;
- Papanastasopoulos, Panagiotis;
- Kaur, Baljeet;
- Sebire, Neil J.;
- Short, Dee;
- Fisher, Rosemary A.;
- Sarwar, Naveed;
- Wells, Michael;
- Singh, Kam;
- Ellis, Laura;
- Horsman, Janet M.;
- Winter, Matthew C.;
- Tidy, John;
- Hancock, Barry W.;
- Seckl, Michael J.
Publication type:
journal article
Emergency Etoposide-Cisplatin (Em-EP) for patients with germ cell tumours (GCT) and trophoblastic neoplasia (TN).
Published in:
2019
By:
- Chan Wah Hak, Charleen;
- Coyle, Christopher;
- Kocache, Arwa;
- Short, Dee;
- Sarwar, Naveed;
- Seckl, Michael J.;
- Gonzalez, Michael A.
Publication type:
journal article
A case of intraplacental gestational choriocarcinoma; characterised by the methylation pattern of the early placenta and an absence of driver mutations.
Published in:
2019
By:
- Savage, Philip;
- Monk, David;
- Hernandez Mora, Jose R.;
- van der Westhuizen, Nick;
- Rauw, Jennifer;
- Tinker, Anna;
- Robinson, Wendy;
- Song, Qianqian;
- Seckl, Michael J.;
- Fisher, Rosemary A.
Publication type:
journal article
Validation of an online tool for early prediction of the failure-risk in gestational trophoblastic neoplasia patients treated with methotrexate.
Published in:
2020
By:
- Dekeister, Kathleen;
- Bolze, Pierre-Adrien;
- Tod, Michel;
- Tod, Rémi;
- Massardier, Jérôme;
- Lotz, Jean-Pierre;
- Hajri, Touria;
- Colomban, Olivier;
- Seckl, Michael J.;
- Osborne, Ray;
- Freyer, Gilles;
- Golfier, François;
- You, Benoit
Publication type:
journal article
Pathological findings after primary chemotherapy in patients undergoing simultaneous orchidectomy and retroperitoneal lymph node dissection for advanced germ cell tumours.
Published in:
BJU International, 2013, v. 111, n. 4b, p. E152, doi. 10.1111/j.1464-410X.2012.11537.x
By:
- Miller, Rowan E.;
- Dudderidge, Tim;
- Huddart, Robert;
- Seckl, Michael J.;
- Rustin, Gordon J.S.;
- Christmas, Timothy J.
Publication type:
Article
A Therapeutic Target for Smoking-Associated Lung Cancer.
Published in:
Science Translational Medicine, 2010, v. 2, n. 62, p. 1, doi. 10.1126/scitranslmed.3001942
By:
- Turner, Nicholas C.;
- Seckl, Michael J.
Publication type:
Article
Crosstalk with lung fibroblasts shapes the growth and therapeutic response of mesothelioma cells.
Published in:
Cell Death & Disease, 2023, v. 14, n. 11, p. 1, doi. 10.1038/s41419-023-06240-x
By:
- Chrisochoidou, Yakinthi;
- Roy, Rajat;
- Farahmand, Pooyeh;
- Gonzalez, Guadalupe;
- Doig, Jennifer;
- Krasny, Lukas;
- Rimmer, Ella F.;
- Willis, Anne E;
- MacFarlane, Marion;
- Huang, Paul H.;
- Carragher, Neil O.;
- Munro, Alison F.;
- Murphy, Daniel J.;
- Veselkov, Kirill;
- Seckl, Michael J.;
- Moffatt, Miriam F.;
- Cookson, William O. C.;
- Pardo, Olivier E.
Publication type:
Article
Tumoral pulmonary hypertension.
Published in:
European Respiratory Review, 2019, v. 28, n. 151, p. 1, doi. 10.1183/16000617.0065-2018
By:
- Price, Laura C.;
- Seckl, Michael J.;
- Dorfmüller, Peter;
- Wort, S. John
Publication type:
Article
Substance P-related antagonists inhibit vasopressin and bombesin but not 5′-3-O-(thio) triphosphate-stimulated inositol phosphate production in swiss 3T3 cells.
Published in:
Journal of Cellular Physiology, 1995, v. 163, n. 1, p. 87, doi. 10.1002/jcp.1041630110
By:
- Seckl, Michael J.;
- Newman, Richard H.;
- Freemont, Paul S.;
- Rozengurt, Enrique
Publication type:
Article
Experiences of Women With Gestational Trophoblastic Neoplasia Treated With High-Dose Chemotherapy and Stem Cell Transplantation: A Qualitative Study.
Published in:
Oncology Nursing Forum, 2017, v. 44, n. 3, p. 375, doi. 10.1188/17.ONF.375-383
By:
- Singh, Kam;
- Warnock, Clare;
- Ireson, Jane;
- Strickland, Sarah;
- Seckl, Michael J.;
- Hancock, Barry W.
Publication type:
Article
Developing an objective marker to optimize patient selection and predict survival benefit in early-phase cancer trials.
Published in:
Cancer (0008543X), 2014, v. 120, n. 2, p. 262, doi. 10.1002/cncr.28381
By:
- Stavraka, Chara;
- Pinato, David J.;
- Turnbull, Samantha J.;
- Flynn, Michael J.;
- Forster, Martin D.;
- O'Cathail, Sean M.;
- Babar, Sayed;
- Seckl, Michael J.;
- Kristeleit, Rebecca S.;
- Blagden, Sarah P.
Publication type:
Article
Mutations in NLRP7 and KHDC3 L Confer a Complete Hydatidiform Mole Phenotype on Digynic Triploid Conceptions.
Published in:
Human Mutation, 2013, v. 34, n. 2, p. 301, doi. 10.1002/humu.22228
By:
- Fallahian, Masoumeh;
- Sebire, Neil J.;
- Savage, Philip M.;
- Seckl, Michael J.;
- Fisher, Rosemary A.
Publication type:
Article
The maternally transcribed gene p57KIP2 (CDNK1C) is abnormally expressed in both androgenetic and biparental complete hydatidiform moles.
Published in:
Human Molecular Genetics, 2002, v. 11, n. 26, p. 3267, doi. 10.1093/hmg/11.26.3267
By:
- Fisher, Rosemary A.;
- Hodges, Matthew D.;
- Rees, Helene C.;
- Sebire, Neil J.;
- Seckl, Michael J.;
- Newlands, Edward S.;
- Genest, David R.;
- Castrillon, Diego H.
Publication type:
Article
Type I interferons modulate methotrexate resistance in gestational trophoblastic neoplasia.
Published in:
American Journal of Reproductive Immunology, 2017, v. 77, n. 6, p. n/a, doi. 10.1111/aji.12666
By:
- Elias, Kevin M.;
- Harvey, Richard A.;
- Hasselblatt, Kathleen T.;
- Seckl, Michael J.;
- Berkowitz, Ross S.
Publication type:
Article
Tumor growth suppression using a combination of taxol-based therapy and GSK3 inhibition in non-small cell lung cancer.
Published in:
PLoS ONE, 2019, v. 14, n. 4, p. 1, doi. 10.1371/journal.pone.0214610
By:
- O’Flaherty, Linda;
- Shnyder, Steven D.;
- Cooper, Patricia A.;
- Cross, Stephen J.;
- Wakefield, James G.;
- Pardo, Olivier E.;
- Seckl, Michael J.;
- Tavaré, Jeremy M.
Publication type:
Article
Investigating the Regulation of Ribosomal Protein S6 Kinase 1 by CoAlation.
Published in:
International Journal of Molecular Sciences, 2024, v. 25, n. 16, p. 8747, doi. 10.3390/ijms25168747
By:
- Malanchuk, Oksana;
- Bdzhola, Anna;
- Palchevskyi, Sergii;
- Bdzhola, Volodymyr;
- Chai, Peng;
- Pardo, Olivier E.;
- Seckl, Michael J.;
- Banerjee, Adrija;
- Peak-Chew, Sew Yeu;
- Skehel, Mark;
- Guruprasad, Lalitha;
- Zhyvoloup, Alexander;
- Gout, Ivan;
- Filonenko, Valeriy
Publication type:
Article
Effectiveness of adjuvant systemic therapy following complete cytoreductive surgery in patients with recurrent granulosa cell tumours of the ovary.
Published in:
Scientific Reports, 2024, v. 14, n. 1, p. 1, doi. 10.1038/s41598-024-51752-x
By:
- Yumru Celiksoy, Harika;
- Dickie, Catriona;
- Seckl, Michael J.;
- Aydın, Esra;
- Sozen, Hamdullah;
- Topuz, Samet;
- Fotopoulou, Christina
Publication type:
Article
Emergency craniotomy: a life-saving procedure as part of multi-modal therapy of GTN.
Published in:
Journal of Gynecologic Oncology, 2022, v. 33, n. 3, p. 1, doi. 10.3802/jgo.2022.33.e52
By:
- Ghorani, Ehsan;
- Seckl, Michael J.
Publication type:
Article
Emerging roles of hnRNPA1 in modulating malignant transformation.
Published in:
Wiley Interdisciplinary Reviews: RNA, 2017, v. 8, n. 6, p. n/a, doi. 10.1002/wrna.1431
By:
- Roy, Rajat;
- Huang, Yueyang;
- Seckl, Michael J.;
- Pardo, Olivier E.
Publication type:
Article
Cover Image, Volume 8, Issue 6.
Published in:
Wiley Interdisciplinary Reviews: RNA, 2017, v. 8, n. 6, p. n/a, doi. 10.1002/wrna.1457
By:
- Roy, Rajat;
- Huang, Yueyang;
- Seckl, Michael J.;
- Pardo, Olivier E.
Publication type:
Article

Found: 51