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- Title
Recurrent Facial Erythema with Cytotoxic T Cell Infiltration as a Possible Reactive Eruption in a Human T-Cell Lymphotropic Virus Type 1 Carrier.
- Authors
Kaneko, Yasuhiro; Tatsuno, Kazuki; Fujiyama, Toshiharu; Ito, Taisuke; Tokura, Yoshiki
- Abstract
Human T-cell lymphotropic virus type 1 (HTLV-1) induces adult T cell leukemia/lymphoma (ATLL), HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and carrier. Approximately half of ATLL patients have direct skin involvement of neoplastic cells. However, there exist HTLV-1-associated reactive eruptions with a predominant infiltrate of non-neoplastic CD8+ T cells in ATLL, HAM/TSP and carrier. A 50-year-old Japanese female HTLV-1 carrier had several episodes of itchy, indurated erythema that occurred diffusely on the face and neck, lasted for 2 weeks and spontaneously subsided without sequelae. Histopathologically, CD3+ T cells infiltrated the upper dermis, and part of the infiltrating cells were CD4+CD25+, sharing the phenotype with ATLL neoplastic cells. An aggregate of CD8+ T cells bearing the cytotoxic molecule TIA-1 was also present. It is possible that skin-affinitive HTLV-1+CD4+ T cells propagated and subsequently disappeared as a result of cytotoxic T cell attack. © 2015 S. Karger AG, Basel
- Subjects
ADULT T-cell leukemia; ERYTHEMA; HTLV-I; PARAPARESIS; T cells; JAPANESE women; FLOW cytometry
- Publication
Case Reports in Dermatology, 2015, Vol 7, Issue 2, p95
- ISSN
1662-6567
- Publication type
Article
- DOI
10.1159/000430804