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- Title
Immunology of Inflammatory Bowel Disease: Molecular Mechanisms and Therapeutics.
- Authors
Lu, Quan; Yang, Mei-feng; Liang, Yu-jie; Xu, Jing; Xu, Hao-ming; Nie, Yu-qiang; Wang, Li-sheng; Yao, Jun; Li, De-feng
- Abstract
As a main digestive organ and an important immune organ, the intestine plays a vital role in resisting the invasion of potential pathogens into the body. Intestinal immune dysfunction remains important pathogenesis of inflammatory bowel disease (IBD). In this review, we explained the interactions among symbiotic flora, intestinal epithelial cells, and the immune system, clarified the operating mechanism of the intestinal immune system, and highlighted the immunological pathogenesis of IBD, with a focus on the development of immunotherapy for IBD. In addition, intestinal fibrosis is a significant complication in patients with long-term IBD, and we reviewed the immunological pathogenesis involved in the development of intestinal fibrogenesis and provided novel antifibrotic immunotherapies for IBD.
- Subjects
INFLAMMATORY bowel diseases; IMMUNOLOGY; DIGESTIVE organs; THERAPEUTICS; IMMUNE system
- Publication
Journal of Inflammation Research, 2022, Vol 15, p1825
- ISSN
1178-7031
- Publication type
Article
- DOI
10.2147/JIR.S353038