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- Title
Carcinosarcoma of the Pancreas: A Unique Case with Emphasis on Metaplastic Transformation and the Presence of Undifferentiated Pleomorphic High-Grade Sarcoma.
- Authors
Hyun-Soo Kim; Sun Hyung Joo; Dal Mo Yang; Sang Hyun Lee; Sung Ho Choi; Sung-Jig Lim
- Abstract
We report a rare case of pancreatic carcinosarcoma in a 48-year-old man. An abdominal ultrasound scan incidentally detected a large heterogeneous mass in the left upper quadrant. CT and MRI scans indicated a rapidly growingunilocular cystic mass in the pancreatic tail. Grossly, the resected pancreatic mass measured 7×5×5 cm and consisted of a unilocular cystic lesion that had several solid mural nodules. Microscopically, the cystic wall showed two carcinomatous components, mucinous cystadenocarcinoma and anaplastic carcinoma. The solid lesion predominantly consisted of pleomorphic spindle cells arranged in interlacing fascicles which had infiltrated the adjacent pancreatic parenchyma. In some areas of this sarcomatous component, anaplastic carcinoma cells intermingled with or transformed into spindle cells. Immunohistochemically, the carcinomatous components were strongly positive for epithelial markers, and transforming anaplastic carcinoma cells were immunoreactive for both epithelial markers and vimentin; in contrast, the sarcomatous component was strongly positive for only vimentin. Additionally, an identical mutation (G to A transition) at codon 12 of K-ras gene and concordant immunoreactivity for p53 protein were detected in the carcinomatous and sarcomatous components. These findings suggested that the pancreatic carcinosarcoma could be of monoclonal origin, and that the sarcomatous component might have arisen from metaplastic transformation of the carcinomatous component.
- Subjects
CANCER cells; GENETIC mutation; MAGNETIC resonance imaging
- Publication
Journal of Gastrointestinal & Liver Diseases, 2011, Vol 20, Issue 2, p197
- ISSN
1841-8724
- Publication type
Case Study