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- Title
Cardiac Arrest During Delivery Hospitalization: A Cohort Study.
- Authors
Ford, Nicole D.; DeSisto, Carla L.; Galang, Romeo R.; Kuklina, Elena V.; Sperling, Laurence S.; Ko, Jean Y.
- Abstract
Cardiac arrest is an uncommon but serious maternal complication. This article describes the rate of cardiac arrest among hospitalized women who were pregnant in the United States in 2017 to 2019 and examines factors associated with those who had cardiac arrest and those who survived. Visual Abstract. Cardiac Arrest During Delivery Hospitalization.: Cardiac arrest is an uncommon but serious maternal complication. This study describes the rate of cardiac arrest among hospitalized women who were pregnant in the United States in 2017 to 2019 and examines factors associated with those who had cardiac arrest and those who survived. Background: Estimates of cardiac arrest occurring during delivery guide evidence-based strategies to reduce pregnancy-related death. Objective: To investigate rate of, maternal characteristics associated with, and survival after cardiac arrest during delivery hospitalization. Design: Retrospective cohort study. Setting: U.S. acute care hospitals, 2017 to 2019. Participants: Delivery hospitalizations among women aged 12 to 55 years included in the National Inpatient Sample database. Measurements: Delivery hospitalizations, cardiac arrest, underlying medical conditions, obstetric outcomes, and severe maternal complications were identified using codes from the International Classification of Diseases, 10th Revision, Clinical Modification. Survival to hospital discharge was based on discharge disposition. Results: Among 10 921 784 U.S. delivery hospitalizations, the cardiac arrest rate was 13.4 per 100 000. Of the 1465 patients who had cardiac arrest, 68.6% (95% CI, 63.2% to 74.0%) survived to hospital discharge. Cardiac arrest was more common among patients who were older, were non-Hispanic Black, had Medicare or Medicaid, or had underlying medical conditions. Acute respiratory distress syndrome was the most common co-occurring diagnosis (56.0% [CI, 50.2% to 61.7%]). Among co-occurring procedures or interventions examined, mechanical ventilation was the most common (53.2% [CI, 47.5% to 59.0%]). The rate of survival to hospital discharge after cardiac arrest was lower with co-occurring disseminated intravascular coagulation (DIC) without or with transfusion (50.0% [CI, 35.8% to 64.2%] or 54.3% [CI, 39.2% to 69.5%], respectively). Limitations: Cardiac arrests occurring outside delivery hospitalizations were not included. The temporality of arrest relative to the delivery or other maternal complications is unknown. Data do not distinguish cause of cardiac arrest, such as pregnancy-related complications or other underlying causes among pregnant women. Conclusion: Cardiac arrest was observed in approximately 1 in 9000 delivery hospitalizations, among which nearly 7 in 10 women survived to hospital discharge. Survival was lowest during hospitalizations with co-occurring DIC. Primary Funding Source: None.
- Subjects
UNITED States; CARDIAC arrest; ADULT respiratory distress syndrome; DISSEMINATED intravascular coagulation; PREGNANCY complications; NOSOLOGY
- Publication
Annals of Internal Medicine, 2023, Vol 176, Issue 4, p472
- ISSN
0003-4819
- Publication type
Article
- DOI
10.7326/M22-2750