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- Title
Calculation of limits for significant unidirectional changes in two or more serial results of a biomarker based on a computer simulation model.
- Authors
Lund, Flemming; Petersen, Per Hyltoft; Fraser, Callum G; Sölétormos, György
- Abstract
The article presents a study which states the need of a simple method to interpret the significance of a difference when all available serial biomarker results are considered. It mentions that the study developed a computer simulation model and computes serial relative differences to give limits for significant unidirectional differences with a constant cumulated maximum probability of both 95%. It is inferred that the limits for significances are easily calculated using the presented factors.
- Subjects
BIOMARKERS; SIMULATION methods &; models; GAUSSIAN distribution; CONTINUOUS distributions; PATIENT monitoring
- Publication
Annals of Clinical Biochemistry, 2015, Vol 52, Issue 2, p237
- ISSN
0004-5632
- Publication type
Article
- DOI
10.1177/0004563214534636