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- Title
Hibiscus sabdariffa calyx palliates insulin resistance, hyperglycemia, dyslipidemia and oxidative rout in fructose-induced metabolic syndrome rats.
- Authors
Ajiboye, Taofeek O; Raji, Hikmat O; Adeleye, Abdulwasiu O; Adigun, Nurudeen S; Giwa, Oluwayemisi B; Ojewuyi, Oluwayemisi B; Oladiji, Adenike T
- Abstract
BACKGROUND The effect of Hibiscus sabdariffa calyx extract was evaluated in high-fructose-induced metabolic syndrome rats. Insulin resistance, hyperglycemia, dyslipidemia and oxidative rout were induced in rats using high-fructose diet. High-fructose diet-fed rats were administered 100 and 200 mg kg−1 body weight of H. sabdariffa extract for 3 weeks, starting from week 7 of high-fructose diet treatment. RESULTS High-fructose diet significantly ( P < 0.05) increased the serum levels of blood glucose, insulin, total cholesterol ( TC), triacylglycerol ( TAG), low-density lipoprotein cholesterol ( LDLc) and very-low-density lipoprotein cholesterol ( VLDLc), with a concomitant reduction in high-density lipoprotein cholesterol ( HDLc). These alterations were significantly ameliorated by the extract. High-fructose diet-mediated decreases in the activities of superoxide dismutase ( SOD), catalase ( CAT), glutathione peroxidase ( GSH-Px), glutathione reductase ( GSH-red) and glucose 6-phosphate dehydrogenase (Glc 6- PD) were significantly ( P < 0.05) attenuated. Altered levels of reduced glutathione ( GSH) and glutathione disulfide ( GSSG) were significantly ( P < 0.05) restored to normal. High-fructose diet-mediated increases in the concentrations of malondialdehyde, conjugated dienes, lipid hydroperoxides, protein carbonyl and percentage fragmented DNA were significantly ( P < 0.05) lowered by the Hibiscus extract. CONCLUSION Overall, aqueous extract of H. sabdariffa palliates insulin resistance, hyperglycemia, dyslipidemia and oxidative rout in high-fructose-induced metabolic syndrome rats. © 2015 Society of Chemical Industry
- Subjects
HIBISCUS; PROINSULIN; BIPHASIC insulin; MALVACEAE; SUCROSE
- Publication
Journal of the Science of Food & Agriculture, 2016, Vol 96, Issue 5, p1522
- ISSN
0022-5142
- Publication type
Article
- DOI
10.1002/jsfa.7254