We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Intravenous Pamidronate in the Treatment of Severe Idiopathic Infantile Hypercalcemia.
- Authors
Skalova, Sylva; Cerna, Lucie; Bayer, Milan; Kutilek, Stepan; Konrad, Martin; Schlingmann, Karl-Peter
- Abstract
Idiopathic infantile hypercalcemia (IIH) is a rare disorder caused by CYP24A1 loss-of-function mutation, resulting in impaired degradation of 1,25-dihydroxyvitamin D3. Pamidronate, an intravenously administered bisphosphonate, which is a potent inhibitor of bone resorption, has been reported only once for treatment IIH. We present a case of a previously healthy 5-monthold boy with IIH, where calcemia peaked to 5 mmol/L. Treatment with methylprednisone and furosemide had only minor effects; therefore, 2 intravenous infusions of pamidronate (0.6 mg/kg per dose) corrected the serum calcium level to 2.95 mmol/L. Furthermore, CYP24A1 homozygous mutation p.R396W (c.1186c>t) was identified in this patient, confirming the clinical diagnosis of IIH. In conclusion, IIH has a favorable outcome once properly detected and appropriately treated. Pamidronate has a beneficial effect in those patients with IIH where glucocorticoids and furosemide fail to meet the expectations.
- Subjects
HYPERCALCEMIA; INFANT disease treatment; FAILURE to thrive syndrome; DISODIUM pamidronate; DIPHOSPHONATES; THERAPEUTICS
- Publication
Iranian Journal of Kidney Diseases, 2013, Vol 7, Issue 2, p160
- ISSN
1735-8582
- Publication type
Case Study