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- Title
Anti-complementary activity of protostane-type triterpenes from Alismatis rhizoma.
- Authors
Lee, Sang; Kim, Jung; Zhang, Ying; An, Ren; Min, Byung; Hyouk, Joung; Hyeong Kyu, Lee
- Abstract
Four protostane-type triterpenes, alisol B 23-acetate ( 1a), alisol C 23-acetate ( 2a), alisol B ( 3a), and alisol A 24-acetate ( 4a), were isolated from the rhizome of Alismatis plantago-aquatica L. var. orientate Samuelson (Alismataceae) and eleven protostane derivatives (compounds 1-11) were obtained by selective modification from alisol B 23-acetate ( 1a). These compounds were investigated for their anti-complement activity against the classical pathway of the complement system. Alisol B ( 3a) and alisol A 24-acetate ( 4a) exhibited anti-complement activity with IC50 values of 150 and 130 μM. Among the synthetic derivatives, the tetrahydroxylated protostane triterpene ( 9) showed moderate inhibitory activity with IC50 value of 97.1 μM. Introduction of an aldehyde group at C-23 ( 10; IC50 value, 47.7 μM) showed the most potent inhibitory effect on the complement system in vitro
- Publication
Archives of Pharmacal Research, 2003, Vol 26, Issue 6, p463
- ISSN
0253-6269
- Publication type
Article
- DOI
10.1007/BF02976863