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- Title
Preoperative Hepatitis B Virus DNA Level is a Risk Factor for Postoperative Liver Failure in Patients Who Underwent Partial Hepatectomy for Hepatitis B-Related Hepatocellular Carcinoma.
- Authors
Huang, Gang; Lau, Wan; Shen, Feng; Pan, Ze-ya; Fu, Si-yuan; Yang, Yun; Zhou, Wei-ping; Wu, Meng-chao
- Abstract
Objective: Our objective was to explore the short-term effects of preoperative serum hepatitis B virus DNA level (HBV DNA) on postoperative hepatic function in patients who underwent partial hepatectomy for hepatitis B-related hepatocellular carcinoma (HCC). Methods: The clinical data of 1,602 patients with hepatitis B-related HCC who underwent partial hepatectomy in our department were retrospectively studied. The patients were divided into three groups according to their preoperative HBV DNA levels: group A <200 IU/mL, group B 200-20,000 IU/mL, and group C >20,000 IU/mL. The rates of postoperative complications, especially the rate of postoperative liver failure, were compared. Results: There were significant differences among the three groups in the rates of postoperative liver failure. On multivariate logistic regression analysis, a high preoperative HBV DNA level was an independent risk factor for postoperative liver failure. Conclusions: Preoperative HBV DNA level was a significant risk factor for postoperative hepatic dysfunction.
- Subjects
HEPATITIS B virus; PREOPERATIVE care; LIVER function tests; HEPATECTOMY; LIVER cancer
- Publication
World Journal of Surgery, 2014, Vol 38, Issue 9, p2370
- ISSN
0364-2313
- Publication type
Article
- DOI
10.1007/s00268-014-2546-7