We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Regulation of intestinal epithelial gene expression in hypoxia.
- Authors
Taylor, Cormac T.
- Abstract
Mucosal hypoxia is intimately associated with chronic inflammation in the gastrointestinal tract in disease such as Crohn's disease. Under such conditions, intestinal epithelial cells may become a source of proinflammatory cytokines, including tumor necrosis factor alpha (TNFalpha), which actively contribute to ongoing inflammation through autocrine disruption of epithelial barrier function. These events are critically dependent upon alterations in the expression and function of the cAMF response element binding protein (CREB). Here we review our understanding of the molecular mechanisms underlying the regulation of CREB activity in intestinal epithelial cells in hypoxia.
- Subjects
HYPOXEMIA; PHYSIOLOGICAL effects of oxygen; GENE expression; EPITHELIAL cells; GASTROINTESTINAL system; CARRIER proteins
- Publication
Kidney International, 2004, Vol 66, Issue 2, p528
- ISSN
0085-2538
- Publication type
journal article
- DOI
10.1111/j.1523-1755.2004.761_12.x