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- Title
Lung metastasis in adenoid cystic carcinoma of the head and neck.
- Authors
Seok, Jungirl; Lee, Doh Young; Kim, Won Shik; Jeong, Woo‐Jin; Chung, Eun‐Jae; Jung, Young Ho; Kwon, Seong Keun; Kwon, Tack‐Kyun; Sung, Myung‐Whun; Ahn, Soon‐Hyun
- Abstract
Background: Distant metastasis of adenoid cystic carcinoma (ACC) is most commonly identified in the lung, but risk factors are still on debate. Methods: Risk factors for lung metastasis were evaluated by using Cox proportional hazards model and Kaplan–Meier curves. Results: Of 112 patients, 48% had distant metastasis; 94.4% of whom had lung metastasis. Univariable analysis revealed sublingual or minor salivary gland, tumor size ≥2.5 cm, and perineural invasion as risk factors (hazard ratio [HR]: 1.99 [1.02–3.91], 2.57 [1.19–5.58], and 2.46 [1.28–4.74], respectively), whereas size, perineural invasion, and local recurrence were risk factors in multivariable analysis (HR: 2.29 [1.05–4.96], 2.32 [1.09–4.96], and 2.68 [1.24–5.79], respectively). Conclusion: Sublingual gland or minor salivary glands ACC has a higher risk of lung metastasis. If the site is not considered, the following factors increased the risk of lung metastasis; (a) size ≥2.5 cm, (b) perineural invasion, and (c) local recurrence.
- Subjects
ADENOID cystic carcinoma; PROPORTIONAL hazards models; SALIVARY glands; LUNGS; METASTASIS; NECK
- Publication
Head & Neck, 2019, Vol 41, Issue 11, p3976
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.25942