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- Title
22-Oxacalcitriol Upregulates p21<sup>WAF1/Cip1</sup> in Human Parathyroid Glands.
- Authors
Shiraishi, Koji; Tsuchida, Masahiro; Wada, Takashi; Yoshihiro, Satoru; Takai, Kimio; Suga, Akinobu; Kaneda, Yoshitaka; Naito, Katsusuke
- Abstract
In the era of 22-oxacalcitriol (OCT), newly synthesized 1α,25-dihydroxyvitamin D3 analogue, against secondary hyperparathyroidism, the indications of parathyroidectomy (PTx) has been restricted. Recent investigations on animal models have revealed the inhibitory effects on PTH secretion after OCT treatment, whereas there has been no evidence about human parathyroid glands. A 38-year-old man with a 19-year history of hemodialysis was performed PTx after the failure of OCT treatment. Expressions of proliferative nuclear cell antigen (PCNA), calcium-sensing receptor (CaSR), vitamin D receptor (VDR), p53 and p21WAF1/Cip1 were analyzed by Western blotting and immunohistochemistry on resected parathroid glands. We confirmed up-regulations of CaSR and VDR, which contribute the reduction of serum PTH, by OCT treatment. Concomitant up-regulation of p21WAF1/Cip1 but not p53, especially in nodular hyperplasia, can be considered to induce cell cycle arrest of the parathyroid cells, but not cytocidal effect of OCT. Copyright © 2001 S. Karger AG, Basel
- Publication
American Journal of Nephrology, 2001, Vol 21, Issue 6, p507
- ISSN
0250-8095
- Publication type
Article
- DOI
10.1159/000046658