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- Title
Expression of Matrix Metalloproteinases in Patients With Uterine Smooth Muscle Tumors: An Immunohistochemical Analysis of MMP-1 and MMP-2 Protein Expression in Leiomyoma, Uterine Smooth Muscle Tumor of Uncertain Malignant Potential, and Leiomyosarcoma.
- Authors
Bodner-Adler, B.; Bodner, K.; Kimberger, O.; Czerwenka, K.; Leodolter, S.; Mayerhofer, K.
- Abstract
Objective:Matrix metalloproteinases (MMPs) have been suggested to play an important role in tumor invasion and metastasis. We compared the expression of MMP-1 and MMP-2 protein in patients with leiomyoma, uterine smooth muscle tumor of uncertain malignant potential (STUMP), and leiomyosarcoma (LMS).Methods:MMP-1 and MMP-2 expression was investigated by immunohistochemistry from paraffin-embedded tissue in 26 patients with leiomyoma, in 24 patients with STUMP, and in 21 patients with LMS.Results:MMP-1 was expressed in 92% of leiomyomas, in 83% of STUMP, and in 86% of LMS, whereas MMP-2 was expressed in 12% of leiomyomas, in 17% of STUMP, and in 48% of LMS. A statistically significant difference regarding the frequency of MMP-2 expression was observed between LMS and STUMP (P = .025) as well as between LMS and leiomyoma (P = .006), but not between STUMP and leiomyoma (P > .05). Likewise, the staining intensity did significantly differ between LMS and leiomyoma (P = .025), but no statistical significant difference was observed between LMS and STUMP (P > .05) and between STUMP and leiomyoma (P > .05).Conclusion:The stronger MMP-2 expression in patients with LMS compared with STUMP and leiomyoma indicates that this protein might be a marker for tumor invasion or metastasis in patients with uterine LMS. Furthermore, MMP-2 seems to be a useful immunohistochemical parameter to distinguish cases of smooth muscle tumors in which histologic features are ambiguous or borderline. Further studies including larger numbers of patients are necessary to establish MMP-2 as a routine marker for tumor invasion and progression.
- Publication
Reproductive Sciences, 2004, Vol 11, Issue 3, p182
- ISSN
1933-7191
- Publication type
Article
- DOI
10.1016/j.jsgi.2003.09.004