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- Title
Maintenance immunosuppressive therapy and generic cyclosporine A use in adult renal transplantation: a single center analysis.
- Authors
Diarra, Danielle A.; Riegersperger, Markus; Säemann, Marcus D; Sunder-Plassmann, Gere
- Abstract
At present, solid organ transplantation relies on chronic immunosuppression. Calcineurin inhibitors (CNIs) still remain one of the most important components in current immunosuppressive regimens. However, life-long immunosuppression of transplant recipients is associated with high costs for the individual, health-care systems, and society. Hence, there is an urgent need of generic drugs that have the potential to exert equivalent therapeutic efficacy at a lower cost. Here, we report our findings of the conversion of 59 stable long-term kidney graft recipients from cyclosporine A (CsA) Neoral to CsA Neoimmun/Equoral. All patients displayed a continuous stable graft function after conversion for a follow-up period of 6 months, and no major side effects associated with the use of CsA Neoimmun/Equoral were observed. Also, CsA dose and trough levels did not differ after conversion to CsA Neoimmun/Equoral. These data indicate that conversion of long-term kidney graft recipients from CsA Neoral to CsA Neoimmun/Equoral is safe and effective, making this specific CsA generic a viable option for CNI therapy in stable renal transplant patients.
- Subjects
IMMUNOSUPPRESSION; TRANSPLANTATION of organs, tissues, etc.; GENERIC drug substitution; IMMUNOREGULATION; DRUG interactions
- Publication
Kidney International Supplement, 2010, Vol 77, pS8
- ISSN
0098-6577
- Publication type
Article
- DOI
10.1038/ki.2009.505