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- Title
Further evidence that methylenetetrahydrofolate reductase A1298C polymorphism is a risk factor for schizophrenia.
- Authors
Chen Zhang; Bin Xie; Yasong Du; Wenhong Cheng; Yiru Fang; Shunying Yu
- Abstract
Previous work suggests that the methylenetetrahydrofolate reductase gene ( MTHFR) functional polymorphism A1298C may be a risk factor for schizophrenia. In this study, the genetic association between the MTHFR A1298C polymorphism and schizophrenia was investigated in 379 patients with schizophrenia and 380 age- and sex-matched controls subjects. The results showed an association between the 1298C allele and the disorder (OR 1.39, 95% confidence interval 1.08–1.79). This provides further evidence that the MTHFR A1298C polymorphism may play a role in conferring risk for schizophrenia in the Chinese Han population.
- Subjects
METHYLENETETRAHYDROFOLATE reductase; GENETIC polymorphisms; SCHIZOPHRENIA; DISEASE risk factors; PEOPLE with schizophrenia; CASE-control method
- Publication
Journal of Neural Transmission, 2010, Vol 117, Issue 9, p1115
- ISSN
0300-9564
- Publication type
Article
- DOI
10.1007/s00702-010-0442-3