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- Title
Wnt signalling in murine postnatal mammary gland development.
- Authors
Jardé, T.; Dale, T.
- Abstract
The mammary gland undergoes numerous developmental processes postnatally, from the elongation of the ductal tree-like structure to pregnancy-induced lobulo-alveolar development. Mammary epithelial stem cells have been suggested to be central to the control of enormous tissue expansion and remodelling during phases of mammary development. The Wnt signalling pathway plays a critical role in these biological steps and is suggested to be involved in the maintenance of the stem cell population. This review provides insight into recent findings on the activity of Wnt signalling during ductal and lobular mammary development and discusses the potential interplay between Wnt signals and mammary stem cells in mice.
- Subjects
MAMMARY glands; EPITHELIAL cells; STEM cells; CELL populations; CELL proliferation
- Publication
Acta Physiologica, 2012, Vol 204, Issue 1, p118
- ISSN
1748-1708
- Publication type
Article
- DOI
10.1111/j.1748-1716.2011.02283.x