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- Title
Down-regulation of the myeloid homeobox protein Hex is essential for normal T-cell development.
- Authors
Mack, David L.; Leibowitz, David S.; Cooper, Scott; Ramsey, Heather; Broxmeyer, Hal E.; Hromas, Robert
- Abstract
The haematopoietic homeobox gene Hex (also called Prh) is expressed in myeloid cells and B cells but not T cells. To investigate whether Hex levels might play a role in myeloid versus T-cell development, two types of transgenic mouse lines were constructed, each with ectopic expression of Hex in T cells (CD11a/Hex and Lck/Hex). Both these types of transgenic mouse had the same defects in T-cell maturation, indicating that proper T-cell development may be dependent not just on the up-regulation of lymphoid-specific transcriptional regulators but also on the co-ordinated down-regulation of myeloid-specific transcriptional regulators such as Hex. In addition, Hex over-expression significantly increased myeloid progenitor cycling, which may explain its role in retrovirally induced murine leukaemia.
- Subjects
HOMEOBOX genes; MYELOID metaplasia
- Publication
Immunology, 2002, Vol 107, Issue 4, p444
- ISSN
0019-2805
- Publication type
Article
- DOI
10.1046/j.1365-2567.2002.01523.x