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- Title
A simple scoring model for advanced colorectal neoplasm in asymptomatic subjects aged 40-49 years.
- Authors
Yoo Mi Park; Hee Sun Kim; Jae Jun Park; Su Jung Baik; Young Hoon Youn; Jie-Hyun Kim; Hyojin Park; Park, Yoo Mi; Kim, Hee Sun; Park, Jae Jun; Baik, Su Jung; Youn, Young Hoon; Kim, Jie-Hyun; Park, Hyojin
- Abstract
<bold>Background: </bold>Limited data are available for advanced colorectal neoplasm in asymptomatic individuals aged 40-49 years. We aimed to identify risk factors and develop a simple prediction model for advanced colorectal neoplasm in these persons.<bold>Methods: </bold>Clinical data were collected on 2781 asymptomatic subjects aged 40-49 years who underwent colonoscopy for routine health examination. Subjects were randomly allocated to a development or validation set. Logistic regression analysis was used to determine predictors of advanced colorectal neoplasm.<bold>Results: </bold>The prevalence of overall and advanced colorectal neoplasm was 20.2 and 2.5% respectively. Older age (45-49 years), male sex, positive serology of Helicobacter pylori, and high triglyceride and low high-density lipoprotein (HDL) levels were independently associated with an increased risk of advanced colorectal neoplasm. BMI (body mass index) was not significant in multivariable analysis. We developed a simple scoring model for advanced colorectal neoplasm (range 0-9). A cutoff of ≥4 defined 43% of subjects as high risk for advanced colorectal neoplasm (sensitivity, 79%; specificity, 58%; area under the receiver operating curve = 0.72) in the validation datasets.<bold>Conclusion: </bold>Older age (45-49 years), male sex, positive serology of H. pylori, high triglyceride level, and low HDL level were identified as independent risk factors for advanced colorectal neoplasm.
- Subjects
COLON cancer; BODY mass index; HIGH density lipoproteins; HELICOBACTER pylori; LOGISTIC regression analysis; AGE distribution; COLON tumors; COLONOSCOPY; COMPARATIVE studies; DECISION making; RESEARCH methodology; MEDICAL cooperation; PHARMACOKINETICS; RECTUM tumors; RESEARCH; RISK assessment; SEX distribution; SYMPTOMS; EVALUATION research; PREDICTIVE tests; DISEASE prevalence; RETROSPECTIVE studies; EARLY detection of cancer; DIAGNOSIS
- Publication
BMC Gastroenterology, 2017, Vol 17, p1
- ISSN
1471-230X
- Publication type
journal article
- DOI
10.1186/s12876-016-0562-9