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- Title
Comparison between quantitative cardiac magnetic resonance perfusion imaging and [15O]H2O positron emission tomography.
- Authors
Everaars, Henk; van Diemen, Pepijn A.; Bom, Michiel J.; Schumacher, Stefan P.; de Winter, Ruben W.; van de Ven, Peter M.; Raijmakers, Pieter G.; Lammertsma, Adriaan A.; Hofman, Mark B. M.; van der Geest, Rob J.; Götte, Marco J.; van Rossum, Albert C.; Nijveldt, Robin; Danad, Ibrahim; Driessen, Roel S.; Knaapen, Paul
- Abstract
Purpose: To compare cardiac magnetic resonance imaging (CMR) with [15O]H2O positron emission tomography (PET) for quantification of absolute myocardial blood flow (MBF) and myocardial flow reserve (MFR) in patients with coronary artery disease (CAD). Methods: Fifty-nine patients with stable CAD underwent CMR and [15O]H2O PET. The CMR imaging protocol included late gadolinium enhancement to rule out presence of scar tissue and perfusion imaging using a dual sequence, single bolus technique. Absolute MBF was determined for the three main vascular territories at rest and during vasodilator stress. Results: CMR measurements of regional stress MBF and MFR showed only moderate correlation to those obtained using PET (r = 0.39; P < 0.001 for stress MBF and r = 0.36; P < 0.001 for MFR). Bland-Altman analysis revealed a significant bias of 0.2 ± 1.0 mL/min/g for stress MBF and − 0.5 ± 1.2 for MFR. CMR-derived stress MBF and MFR demonstrated area under the curves of respectively 0.72 (95% CI: 0.65 to 0.79) and 0.76 (95% CI: 0.69 to 0.83) and had optimal cutoff values of 2.35 mL/min/g and 2.25 for detecting abnormal myocardial perfusion, defined as [15O]H2O PET-derived stress MBF ≤ 2.3 mL/min/g and MFR ≤ 2.5. Using these cutoff values, CMR and PET were concordant in 137 (77%) vascular territories for stress MBF and 135 (80%) vascular territories for MFR. Conclusion: CMR measurements of stress MBF and MFR showed modest agreement to those obtained with [15O]H2O PET. Nevertheless, stress MBF and MFR were concordant between CMR and [15O]H2O PET in 77% and 80% of vascular territories, respectively.
- Subjects
CARDIAC magnetic resonance imaging; POSITRON emission tomography; PERFUSION; STRESS echocardiography; CARDIOGRAPHIC tomography; WATER; BLOOD flow; SCARS
- Publication
European Journal of Nuclear Medicine & Molecular Imaging, 2020, Vol 47, Issue 7, p1688
- ISSN
1619-7070
- Publication type
Article
- DOI
10.1007/s00259-019-04641-9