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- Title
CEAS: cis-regulatory element annotation system.
- Authors
Hyunjin Shin; Tao Liu; Manrai, Arjun K.; X. Shirley Liu
- Abstract
Summary: We present a tool designed to characterize genome-wide protein–DNA interaction patterns from ChIP-chip and ChIP-Seq data. This stand-alone extension of our web application CEAS (cis-regulatory element annotation system) provides summary statistics on ChIP enrichment in important genomic regions such as individual chromosomes, promoters, gene bodies or exons, and infers the genes most likely to be regulated by the binding factor under study. CEAS also enables biologists to visualize the average ChIP enrichment signals over specific genomic regions, particularly allowing observation of continuous and broad ChIP enrichment that might be too subtle to detect from ChIP peaks alone.
- Subjects
PROTEIN analysis; GENOMES; DNA-protein interactions; DNA-ligand interactions; BIOINFORMATICS; RESEARCH
- Publication
Bioinformatics, 2009, Vol 25, Issue 19, p2605
- ISSN
1367-4803
- Publication type
Article
- DOI
10.1093/bioinformatics/btp479