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- Title
Vα14 NKT cell-mediated anti-tumor responses and their clinical application.
- Authors
Seino, Ken-ichiro; Fujii, Shin-ichiro; Harada, Michishige; Motohashi, Shinichiro; Nakayama, Toshinori; Fujisawa, Takehiko; Taniguchi, Masaru
- Abstract
A unique lymphocyte population, Vα14 NKT cells, has recently been revealed to be a key player in the immune responses against tumors. Activation of Vα14 NKT cells affects various cell types, particularly dendritic cells (DCs), NK cells, CD4 Th1 cells, and CD8 cytotoxic T cells in the innate and acquired immune systems, eventually resulting in the enhanced activation of NKT cell-mediated cellular cascade in the anti-tumor responses. The specific ligand, α-galactosylceramide (α-GalCer), effectively stimulates mouse and human NKT cells, making NKT cells an ideal target for the development of cancer immunotherapy. Clinical trials using α-GalCer have actually started in several centers in the world. In this review, we summarize the Vα14 NKT cell-mediated cellular cascade in the anti-tumor response in mice and discuss potential clinical applications of α-GalCer-pulsed DC therapy.
- Subjects
LYMPHOCYTES; KILLER cells; DENDRITIC cells; T cells; IMMUNE system; IMMUNOTHERAPY
- Publication
Springer Seminars in Immunopathology, 2005, Vol 27, Issue 1, p65
- ISSN
0344-4325
- Publication type
Article
- DOI
10.1007/s00281-004-0194-y