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- Title
Ascites formation accompanied by portal vein thrombosis after porcine islet xenotransplantation via the portal vein in Rhesus macaque (Macaca mulatta).
- Authors
Kim, Jong‐Min; Shin, Jun‐Seop; Han, Sungyoung; Min, Byoung‐Hoon; Jeong, Won Young; Lee, Ga Eul; Kim, Min Sun; Kwon, Seeun; Chung, Hyunwoo; Kang, Hee Jung; Park, Chung‐Gyu
- Abstract
Pig‐to‐nonhuman primate (NHP) islet transplantation has been widely conducted as a preclinical xenotransplantation model prior to human clinical trial. Portal vein thrombosis is one of the complications associated with islet infusion through the portal vein into the liver. Here, we briefly report severe case of ascites formation accompanied by portal vein thrombi after pig‐to‐NHP islet xenotransplantation in a rhesus monkey. Meticulous prophylactic treatment such as continuous heparin infusion should be implemented to prevent portal vein thrombi in pig‐to‐NHP islet transplantation models.
- Subjects
PORTAL vein; RHESUS monkeys; XENOGRAFTS; ISLANDS of Langerhans; ASCITES
- Publication
Xenotransplantation, 2019, Vol 26, Issue 1, pN.PAG
- ISSN
0908-665X
- Publication type
Article
- DOI
10.1111/xen.12460