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- Title
Oxalate nephropathy is a major cause of kidney injury in surgically treated pancreatic adenocarcinoma patients.
- Authors
Desbuissons, Geoffroy; Izzedine, Hassan; Bardier, Armelle; Dubreuil, Olivier; Vaillant, Jean Christophe; Frochot, Vincent; Mercadal, Lucile
- Abstract
Background Despite new therapeutics, the prognosis for pancreatic cancer remains poor. Pancreatic surgery is a therapeutic option in non-metastatic forms. The consequences for renal function are poorly described. Methods Patients who underwent surgery for pancreatic cancer between 1 January 2010 and 1 January 2017 and who experienced kidney biopsy in the Pitié-Salpêtrière Hospital were analysed. Results Two hundred and ninety-four patients had pancreatic surgery during the period of analysis and five of them had a kidney biopsy (mean ± SD 20 months ±13.6 months after surgery) during the post-operative follow-up. Among these patients, three exhibited oxalate nephropathy (ON), indicating that the prevalence of ON in patients with pancreatectomy is at least 1%. ON may be insidious, with chronic renal failure without urinary abnormalities. All patients had a high oxalate-to-creatinine ratio in urine sample. Renal function improved after specific management of ON in two patients. Pancreaticoduodenectomy may represent a higher risk of ON than left pancreatectomy. Conclusion Although rare and underestimated, ON appears to be a real risk after pancreatic resection. Early detection may preserve renal function.
- Subjects
KIDNEY injuries; PANCREATIC surgery; INTERSTITIAL nephritis; CHRONIC kidney failure; KIDNEY diseases; PANCREATIC fistula; RENAL biopsy; PANCREATIC cancer
- Publication
Clinical Kidney Journal, 2019, Vol 12, Issue 6, p821
- ISSN
2048-8505
- Publication type
Article
- DOI
10.1093/ckj/sfz015