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- Title
The convergence of senescence and nutrient sensing during lymphocyte ageing.
- Authors
Akbar, A. N.
- Abstract
Immunosurveillance requires the migration of lymphocytes and their activation to induce proliferation and effector function. Effective immunity requires an optimal supply of nutrients to lymphocytes. Cells contain nutrient sensing apparatus such as adenosine 5′-monophosphate-activated protein kinase (AMPK) that surveys intracellular ATP levels. Immunity declines during ageing and one possibility is that the energy balance may be altered in old lymphocytes. This paper summarizes recent data identifying a convergence of senescence and nutrient signalling pathways in lymphocytes that inhibit both T cell and natural killer (NK) cell function during ageing. Significantly, these pathways can be inhibited to enhance the activity of these cells.
- Subjects
LYMPHOCYTE aging; CELL migration; CELL proliferation; PROTEIN kinases; KILLER cells
- Publication
Clinical & Experimental Immunology, 2017, Vol 187, Issue 1, p4
- ISSN
0009-9104
- Publication type
Article
- DOI
10.1111/cei.12876