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- Title
Expression patterns of FCγ receptors, HLA-DR and selected adhesion molecules on monocytes from normal and HIV-infected individuals.
- Authors
Locher, Ch.; Vanham, G.; Kestens, L.; Kruger, M.; Ceuppens, J. L.; Vingerhoets, J.; Gigase, P.
- Abstract
The expression and co-expression profiles of functionally important monocyte surface markers were compared between control and HIV+ individuals using combined physical gating and dim CD4 expression to delineate the monocytes. The FcγRII (CD32), the MHC class II antigen HLA-DR and the adhesion molecules CD11a (LFA-1α), CD18 and CD54 (ICAM-1) showed an unimodal distribution. Of these markers, CD11a and HLA-DR were up-regulated in the HIV+ subjects compared with controls. The expression levels of the adhesion molecules correlated with each other in both patients and controls. The CD11b (CR3-α), CD14, FcγRI, and FcγRIII markers were bimodally distributed. Compared with controls, monocytes from seropositives contained fewer CD14bright+ cells, an equal proportion of FcγRIbright+ cells, but twice as many FcγRIII+ cells. The expression level of FcγRI and CD11b within their brightly positive subset increased as CD4T cells decreased. Both in patients and controls., co-expression of bright CD11b, CD14 and FcγRI was shown, whereas the FcγRIII+ cells were negative or dim positive for the former triad. We conclude that the expression of two FcγR (I and III), of the adhesion molecules CD11a and CD11b and of HLA-DR showed particular alterations on monocytes from HIV+ subjects. The relationship of these phenotypic observations with altered cytokine profiles and altered monocyte function is discussed.
- Subjects
MONOCYTES; HIV; ADHESION; MOLECULES; PHENOTYPES; RECEPTOR antibodies
- Publication
Clinical & Experimental Immunology, 1994, Vol 98, Issue 1, p115
- ISSN
0009-9104
- Publication type
Article
- DOI
10.1111/1365-2249.ep15984992