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- Title
Effects of cyclosporin A on water-immersion stress-induced gastric lesion and gastric secretion in rats.
- Authors
Odashima, Masaru; Otaka, Michiro; Ito, Satoshi; Iwabuchi, Akira; Wada, Isao; Konishi, Noriaki; Pacheco, Ivan; Sato, Toshihiro; Kato, Sayuri; Watanabe, Sumio; Odashima, M; Otaka, M; Ito, S; Iwabuchi, A; Wada, I; Konishi, N; Pacheco, I; Sato, T; Kato, S; Watanabe, S
- Abstract
Cyclosporin A is an immunosuppressive agent which is well known as a specific inhibitor of calcineurin (protein phosphatase 2B). In this study, we investigated the effects of cyclosporin A on water-immersion stress-induced gastric ulcer formation and gastric acid secretion in rats. We also examined the localization of calcineurin immunohistochemically. Calcineurin was specifically expressed in gastric parietal cells and chief cells of the gastric mucosa. The intraperitoneal administration of cyclosporin A dose-dependently suppressed the development of gastric mucosal lesions induced by water-immersion stress and inhibited gastric acid secretion, as assessed by pylorus ligation. These results indicated that calcineurin may play an important role in gastric acid secretion.
- Subjects
CYCLOSPORINE; IMMUNOSUPPRESSIVE agents; GASTRIC acid; SECRETION; PEPTIC ulcer prevention; ANIMAL experimentation; COMPARATIVE studies; DOSE-effect relationship in pharmacology; GASTRIC mucosa; HYDROLASES; INJECTIONS; RESEARCH methodology; MEDICAL cooperation; PEPTIC ulcer; RATS; RESEARCH; PHYSIOLOGICAL stress; WATER; EVALUATION research; PHARMACODYNAMICS
- Publication
Journal of Gastroenterology, 2000, Vol 35, Issue 5, p369
- ISSN
0944-1174
- Publication type
journal article
- DOI
10.1007/s005350050362