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- Title
Suppression of progenitor cell growth by vancomycin following autologous stem cell transplantation.
- Authors
Meehan, K R; Verma, U N; Esteva-Lorenzo, F; Mazumder, A
- Abstract
The occurrence of hematologic side-effects resulting from the use of vancomycin is rare. Prior to this report, vancomycin-induced neutropenia was believed to be due to a hypersensitivity reaction since antibodies directed against circulating neutrophils have been discovered in the serum of some patients. We demonstrate suppression of hematopoietic bone marrow progenitor cells in a patient experiencing vancomycin-induced neutropenia after an autologous hematopoietic stem cell transplantation for multiple myeloma. A bone marrow (BM) specimen obtained at the time of neutropenia demonstrated direct suppression of progenitor cell growth in vitro when vancomycin was added at increasing concentrations (1, 10 and 50 μ g/ml). No such trend was noted in a BM sample from the same patient obtained 11 months prior to transplantation and a normal control BM. The decrease in the total number of colony-forming units (CFU) was statistically significant at all the dose levels of vancomycin when compared to the number of CFU in the baseline BM sample (P < 0.05). the myeloid maturation arrest observed in the bone marrow sample obtained during the period of neutropenia and the dose dependent growth inhibition by vancomycin observed in vitro suggest a novel nonimmune mechanism of hematologic effects due to suppression of bone marrow progenitor cell growth.
- Subjects
STEM cell transplantation; CELL growth; VANCOMYCIN
- Publication
Bone Marrow Transplantation, 1997, Vol 19, Issue 10, p1029
- ISSN
0268-3369
- Publication type
Article
- DOI
10.1038/sj.bmt.1700780