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- Title
Kidney-limited thrombotic microangiopathy in patients with SLE treated with romiplostim.
- Authors
Tomov, S; Lazarchick, J; Self, SE; Bruner, ET; Budisavljevic, MN
- Abstract
We present the case of a 19 year-old Caucasian female with history of systemic lupus erythematosus (SLE) and normal baseline kidney function who developed severe acute renal failure following treatment of thrombocytopenia with the thrombopoietic agent romiplostim. Percutaneous kidney biopsy revealed thrombotic microangiopathy (TMA) without immune complex lupus glomerulonephritis. We discuss pathogenesis and differential diagnosis of TMA in patients with SLE and raise concerns regarding the use of thrombopoietic agents in such patients. Based on favorable long-term outcome in our case aggressive treatment and in particular prolonged use of plasma exchange in these patients are advocated.
- Subjects
THROMBOTIC microangiopathies; SYSTEMIC lupus erythematosus; DIFFERENTIAL diagnosis; AUTOIMMUNE diseases; BIOPSY; BLOOD platelet disorders
- Publication
Lupus, 2013, Vol 22, Issue 5, p504
- ISSN
0961-2033
- Publication type
Article
- DOI
10.1177/0961203313477900