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- Title
Validation of a Point-of-Care Optical Coherence Tomography Device with Machine Learning Algorithm for Detection of Oral Potentially Malignant and Malignant Lesions.
- Authors
James, Bonney Lee; Sunny, Sumsum P.; Heidari, Andrew Emon; Ramanjinappa, Ravindra D.; Lam, Tracie; Tran, Anne V.; Kankanala, Sandeep; Sil, Shiladitya; Tiwari, Vidya; Patrick, Sanjana; Pillai, Vijay; Shetty, Vivek; Hedne, Naveen; Shah, Darshat; Shah, Nameeta; Chen, Zhong-ping; Kandasarma, Uma; Raghavan, Subhashini Attavar; Gurudath, Shubha; Nagaraj, Praveen Birur
- Abstract
Simple Summary: Early detection is crucial towards improving survival in patients diagnosed with oral cancer. Non-invasive strategies equivalent to histology diagnosis are extremely valuable in oral cancer screening and early detection in resource-constrained settings. Optical coherence tomography (OCT), an optical biopsy technique enables real-time imaging with periodic surveillance and capability to image architectural features of the tissues. We report that while OCT system delineates oral pre-cancer and cancer with more than 90% sensitivity, integration, with artificial neural network-based analysis efficiently identifies high-risk, oral pre-cancer (83%). This study provides evidence that the robust, low-cost system was effective as a point-of-care device in resource-constrained settings. The high accuracy and portability signify widespread clinical application in oral cancer screening and/or surveillance. Non-invasive strategies that can identify oral malignant and dysplastic oral potentially-malignant lesions (OPML) are necessary in cancer screening and long-term surveillance. Optical coherence tomography (OCT) can be a rapid, real time and non-invasive imaging method for frequent patient surveillance. Here, we report the validation of a portable, robust OCT device in 232 patients (lesions: 347) in different clinical settings. The device deployed with algorithm-based automated diagnosis, showed efficacy in delineation of oral benign and normal (n = 151), OPML (n = 121), and malignant lesions (n = 75) in community and tertiary care settings. This study showed that OCT images analyzed by automated image processing algorithm could distinguish the dysplastic-OPML and malignant lesions with a sensitivity of 95% and 93%, respectively. Furthermore, we explored the ability of multiple (n = 14) artificial neural network (ANN) based feature extraction techniques for delineation high grade-OPML (moderate/severe dysplasia). The support vector machine (SVM) model built over ANN, delineated high-grade dysplasia with sensitivity of 83%, which in turn, can be employed to triage patients for tertiary care. The study provides evidence towards the utility of the robust and low-cost OCT instrument as a point-of-care device in resource-constrained settings and the potential clinical application of device in screening and surveillance of oral cancer.
- Subjects
MEDICAL equipment reliability; DIGITAL image processing; SUPPORT vector machines; MOUTH tumors; CLINICAL trials; BIOPSY; POINT-of-care testing; EARLY detection of cancer; DIFFERENTIAL diagnosis; COMPARATIVE studies; SEVERITY of illness index; CANCER patients; OPTICAL coherence tomography; DESCRIPTIVE statistics; ARTIFICIAL neural networks; MEDICAL equipment; ALGORITHMS
- Publication
Cancers, 2021, Vol 13, Issue 14, p3583
- ISSN
2072-6694
- Publication type
Article
- DOI
10.3390/cancers13143583