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- Title
Is the gold standard concerning eradication therapy of Helicobacter pylori infection still up-to-date in children and teenagers?
- Authors
Bała, Grażyna; Parzęcka, Monika; Szaflarska-Poplawska, Anna; Mierzwa, Grażyna
- Abstract
Introduction: The regimens of eradication therapy have changed for the last years. The triple therapy including 3 types of drugs is now believed to be a "gold standard" in Helicobacterpylori (H. pylon) eradication in children and teenagers. It is recommended to use proton pump inhibitor (PPI) with two antibiotics: amoxicillin, metronidazole, clarithromycin. Considedng the resistance of H. pylon strains in Poland, Polish Society of Gastroenterology does not advice combining metronidazole and clarithromycin for the first-line treatment. Aim of study: The aim of this study is to estimate the efficacy of the triple eradication therapy in children and teenagers. Material and methods: The efficacy of 7-day eradication therapy was analysed on the basis of patients' medical documentation. The analysis included 104 patients aged from 4 to 18 years (average age - 13.25; 72 girls and 32 boys). 86 patients were treated with omeprazole, amoxicilin and clarithromycin, the other 18 patients used amoxicillin and metronidazole. The evaluation of eradication efficacy was based on endoscopic examination with histopathological assessment oron respiratory test, using urea labeling with C13 carbon. The follow up examination was per- formed not before 4 weeks after the end of therapy. Results: Eradication was unsuccessful in 23 patients treated with omeprazole, amoxicillin and clarithromycin (22.1%) and in 9 patients treated with omeprazole, amoxicillin and metronidazole (8.6%). In summary, eradication was unsuccessful in 32 patients, which made 30.7%. Eradication was unsuccessful even in 9 patients from the group of 18 children and teenagers (50%) treated with omeprazole, amoxicillin and metronidazole. In the group of 86 patients treated with omeprazole, amoxicillin and clarithromycin, eradication was unsuccessful in 23 patients (26.7%). Conclusions: The possibility of changing the currently advised regimen concerning eradication therapy of Helicobactenpylori infection in children and teenagers should be taken into consideration.
- Subjects
HELICOBACTER pylori infections; THERAPEUTICS; ANTISEPTIC medication; PROTON pump inhibitors; ANTIBIOTICS; GASTROENTEROLOGY
- Publication
Gastroenterologia Polska / Gastroenterology, 2007, Vol 14, Issue 1, p27
- ISSN
1232-9886
- Publication type
Article