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- Title
Live birth after fresh versus frozen single blastocyst transfer (Frefro-blastocyst): study protocol for a randomized controlled trial.
- Authors
Daimin Wei; Yun Sun; Jiayin Liu; Xiaoyan Liang; Yimin Zhu; Yuhua Shi; Zi-Jiang Chen; Wei, Daimin; Sun, Yun; Liu, Jiayin; Liang, Xiaoyan; Zhu, Yimin; Shi, Yuhua; Chen, Zi-Jiang
- Abstract
<bold>Background: </bold>Multiple pregnancies are one of the major safety concerns of in vitro fertilization (IVF) due to the increased risk of maternal and neonatal complications. Single embryo transfer is the most effective way to reduce the risk of multiple pregnancies. Selection of the embryo and optimization of the implantation environment are crucial to retain the success rate when the number of transferred embryos is diminished. Fresh embryo transfer with supra-physiological levels of hormones has been suggested to have an adverse effect on implantation. Elective frozen embryo transfer has been suggested to result in a higher rate of live birth than fresh embryo transfer. However, there is still a lack of evidence from randomized clinical trials comparing the efficacy and safety between frozen and fresh single blastocyst transfers.<bold>Methods/design: </bold>We are conducting a randomized controlled trial in women aged 20-35 undergoing their first cycle of IVF with or without intracytoplasmic sperm injection. After ovarian stimulation with a gonadotropin-releasing hormone antagonist protocol, women who obtain four or more embryos on day 3 of the embryo culture are randomized into two parallel groups: a single fresh blastocyst transfer group and a single frozen blastocyst transfer group (all blastocysts vitrified and a deferred frozen blastocyst transfer). The primary outcome is singleton live birth.<bold>Discussion: </bold>The results of this study will provide evidence for the efficacy and safety of the strategy of elective frozen single blastocyst transfer in women with a good prognosis.<bold>Trial Registration: </bold>Chinese Clinical Trial Registry, ChiCTR-IOR-14005405 . Registered on 30 Oct 2014.
- Subjects
CHINA; FERTILIZATION in vitro; EMBRYOS; HORMONES; FROZEN human embryos; CHILDBIRTH; INFERTILITY treatment; BLASTOCYST; BIRTH rate; COMPARATIVE studies; CRYOPRESERVATION of organs, tissues, etc.; EMBRYO transfer; EXPERIMENTAL design; FERTILITY; INFERTILITY; RESEARCH methodology; EVALUATION of medical care; MEDICAL cooperation; RESEARCH protocols; INDUCED ovulation; PREGNANCY; RESEARCH; TIME; EVALUATION research; RANDOMIZED controlled trials; TREATMENT effectiveness; DIAGNOSIS
- Publication
Trials, 2017, Vol 18, p1
- ISSN
1745-6215
- Publication type
journal article
- DOI
10.1186/s13063-017-1993-5