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- Title
SAMHD1 does it again, now in resting T cells.
- Authors
Yan, Nan; Lieberman, Judy
- Abstract
The article focuses on a study which shows that HIV-1 fails to replicate in resting CD4+ T cells while it starts replicating in an activated CD4+ T lymphocytes. It depicts that host deoxynucleoside triphosphate triphosphohydrolase (dNTPase) and aspartic domain-containing protein 1 (SAMHD1) block HIV infection in myeloid cells by hydrolyzing dNTPs which is essential for reverse transcription. It informs that myeloid cells contain one percent dNTPs in activated T cells.
- Subjects
HIV; CD4 antigen; T cells; PHOSPHATASES; HIV infections; REVERSE transcriptase polymerase chain reaction
- Publication
Nature Medicine, 2012, Vol 18, Issue 11, p1611
- ISSN
1078-8956
- Publication type
Article
- DOI
10.1038/nm.2980