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- Title
Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia.
- Authors
Ntziachristos, Panagiotis; Tsirigos, Aristotelis; Vlierberghe, Pieter Van; Nedjic, Jelena; Trimarchi, Thomas; Flaherty, Maria Sol; Ferres-Marco, Dolors; da Ros, Vanina; Tang, Zuojian; Siegle, Jasmin; Asp, Patrik; Hadler, Michael; Rigo, Isaura; Keersmaecker, Kim De; Patel, Jay; Huynh, Tien; Utro, Filippo; Poglio, Sandrine; Samon, Jeremy B; Paietta, Elisabeth
- Abstract
The article presents a study concerning the genetic inactivation of the Polycomb repressive complex 2 (PRC2) in T cell acute lymphoblastic leukemia (T-ALL). It notes that the development of T-ALL is caused by oncogenic activation of NOTCH1 signaling which induces loss of the repressive mark Lys27 trimethylation of histone 3, antagonizing the activity of PRC2. It also mentions the involvement of PRC2 in human leukemia as well as the role of NOTCH1 and PRC2 in the regulation of gene expression.
- Subjects
POLYCOMB group proteins; T cells; LYMPHOBLASTIC leukemia; HISTONES; GENETIC regulation
- Publication
Nature Medicine, 2012, Vol 18, Issue 2, p298
- ISSN
1078-8956
- Publication type
Article
- DOI
10.1038/nm.2651