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- Title
Low Dose Rate Radiation Regulates M2-like Macrophages in an Allergic Airway Inflammation Mouse Model.
- Authors
Jo, Wol Soon; Kang, Sohi; Jeong, Soo Kyung; Bae, Min Ji; Lee, Chang Geun; Son, Yeonghoon; Lee, Hae-June; Jeong, Min Ho; Kim, Sung Ho; Moon, Chongjong; Shin, In Sik; Kim, Joong Sun
- Abstract
We investigated the effects of low dose rate radiation (LDR) on M1 and M2 macrophages in an ovalbumin-induced mouse model of allergic airway inflammation and asthma. After exposure to LDR (1 Gy, 1.818 mGy/h) for 24 days, mice were euthanized and the changes in the number of M1 and M2 macrophages in the bronchoalveolar lavage fluid and lung, and M2-associated cytokine levels, were assessed. LDR treatment not only restored the M2-rich microenvironment but also ameliorated asthma-related progression in a macrophage-dependent manner. In an ovalbumin-induced mouse model, LDR treatment significantly inhibited M2, but not M1, macrophage infiltration. M2-specific changes in macrophage polarization during chronic lung disease reversed the positive effects of LDR. Moreover, the levels of cytokines, including chemokine (C-C motif) ligand (CCL) 24, CCL17, transforming growth factor beta 1, and matrix metalloproteinase-9, decreased in ovalbumin-sensitized/challenged mice upon exposure to LDR. Collectively, our results indicate that LDR exposure suppressed asthmatic progression, including mucin accumulation, inflammation, and Type 2 T helper (Th2) cytokine (interleukin (IL)-4 and IL-13) production. In conclusion, LDR exposure decreased Th2 cytokine secretion in M2 macrophages, resulting in a reduction in eosinophilic inflammation in ovalbumin-sensitized/challenged mice.
- Subjects
OVALBUMINS; TRANSFORMING growth factors-beta; MACROPHAGES; LABORATORY mice; ANIMAL disease models; OVUM; RADIATION doses
- Publication
Dose-Response, 2022, Vol 20, Issue 3, p1
- ISSN
1559-3258
- Publication type
Article
- DOI
10.1177/15593258221117349