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- Title
Glucocorticoid receptor deficiency increases vulnerability of the nigrostriatal dopaminergic system: critical role of glial nitric oxide.
- Authors
Morale, Maria Concetta; Serra, Pier Andrea; Delogu, Maria Rosaria; Migheli, Rossana; Rocchitta, Gaia; Tirolo, Cataldo; Caniglia, Salvo; Testa, Nuccio; L'episcopo, Francesca; Gennuso, Florinda; Scoto, Giovanna M.; Barden, Nicholas; Miele, Egidio; Desole, Maria Speranza; Marchetti, Bianca
- Abstract
Deals with a study which investigated the inflammatory process involved in dopaminergic nigrostriatal neuron loss in Parkinson's disease in mice. Effect of lifelong glucocorticoid receptor (GR) deficiency on vulnerability 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP); Assessment of recovery from MPTP-induced dopaminergic neurotoxicity; Key findings on the embryonic expression of a defective GR.
- Subjects
INFLAMMATION; PARKINSON'S disease; NEUROTOXICOLOGY; DOPAMINERGIC neurons; DOPAMINERGIC mechanisms; SYMPATHETIC nervous system; PATHOLOGICAL physiology; LABORATORY mice
- Publication
FASEB Journal, 2004, Vol 18, Issue 1, p164
- ISSN
0892-6638
- Publication type
Article
- DOI
10.1096/fj.03-0501fje