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- Title
An atomic detail model for the human ATP binding cassette transporter P-glycoprotein derived from disulfide cross-linking and homology modeling.
- Authors
Stenham, Daniella R.; Campbell, Jeff D.; Sansom, Mark S. P.; Higgins, Christopher F.; Kerr, Ian D.; Linton, Kenneth J.
- Abstract
Applies complementary research techniques in the form of experimental cysteine-directed chemical cross-linking and computational homology modeling to produce an atomic scale model for the human multidrug transporter P-glycoprotein (P-gp). Domains of P-gp; Cross-linking analysis of P-gp mutant isoforms; Reconciliation of cross-linking data with a P-gp model.
- Subjects
P-glycoprotein; GLYCOPROTEINS; CYSTEINE proteinases; HOMOLOGY (Biology); PROTEIN crosslinking
- Publication
FASEB Journal, 2003, Vol 17, Issue 15, p2287
- ISSN
0892-6638
- Publication type
Article
- DOI
10.1096/fj.03-0107fje