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- Title
Umbilical Cord Blood Transplantation for Myelodysplastic Syndromes with Donor-Specific Anti-HLA Antibodies against HLA-DP.
- Authors
Yusuke Uchibori; Koichi Onodera; Yasushi Onishi; Hiroka Komatsu; Kenta Takenaka; Yoshihiro Narumi; Tatsuya Watanabe; Hiroshi Nakamura; Kazuki Sakurai; Kazuki Hashimoto; Kyoko Inokura; Satoshi Ichikawa; Noriko Fukuhara; Hisayuki Yokoyama; Hideo Harigae
- Abstract
The presence of donor-specific anti-human leukocyte antigen (HLA) antibodies (DSAs) against anti-HLA-A, -B, -C, and -DRB1 in HLA-mismatched hematopoietic stem cell transplantation (HSCT) is associated with graft failure. DSAs against HLA-A, -B, -C, and -DRB1 with a mean fluorescence intensity (MFI) of greater than > 1,000 was shown to increase the risk of graft failure in single-unit umbilical cord blood transplantation (UCBT). Nevertheless, the impact of DSAs against HLA-DP or -DQ on transplantation outcomes is not fully understood. In this report, we present a case of UCBT in a patient with myelodysplastic syndrome who was positive for DSAs against HLA-DP with MFI of 1,263 before UCBT but successfully achieved neutrophil engraftment. If HLA-DP or -DQ is mismatched in UCBT, evaluating DSAs against HLA-DP or -DQ is crucial to avoid graft failure. However, the criteria for DSAs against HLA-A, -B, -C, and -DRB1 may not be directly applicable to those against HLA-DP or -DQ.
- Subjects
CORD blood transplantation; MYELODYSPLASTIC syndromes; HEMATOPOIETIC stem cell transplantation; IMMUNOGLOBULINS
- Publication
Tohoku Journal of Experimental Medicine, 2023, Vol 261, Issue 2, p123
- ISSN
0040-8727
- Publication type
Article
- DOI
10.1620/tjem.2023.J063