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- Title
Primary cutaneous B-cell lymphoma: A single-center 5-year experience.
- Authors
Jacob, Linu Abraham; Asati, Vikas; K. C., Lakshmaiah; K., Govind Babu; Lokanatha, Dasappa; M. C., Suresh Babu; K. N., Lokesh; A. H., Rudresh; L. K., Rajeev; Mulchandani, Nikita J.; Anand, Abhishek; Koppaka, Deepak; Mysore, Suma Narayana; Lakshmaiah, K C; Govind, Babu K; Babu, Suresh Mc; Lokesh, K N; Rudresh, A H; Rajeev, L K
- Abstract
<bold>Background: </bold>Skin is the second most common site for extranodal non-Hodgkin's lymphoma (NHL). Most primary cutaneous NHLs are of T-cell origin (70%). Primary cutaneous B-cell lymphoma (PCBCL) is a rare entity.<bold>Materials and Methods: </bold>Patients diagnosed with PCBCL between January 2012 and July 2017 at our center were retrospectively analyzed.<bold>Results: </bold>Eight patients of PCBCL were diagnosed. Three patients (37.5%) were males while 5 patients (62.5%) were females. The median age at diagnosis was 45 years (range, 18-60 years). Scalp was the most common site of involvement (50% of the patients). Diffuse large B-cell lymphoma (DLBCL) was the most common histology (63%), with leg-type DLBCL diagnosed in 1 patient. Two patients had primary cutaneous follicle center lymphoma, whereas the remaining 1 patient had precursor B-lymphoblastic lymphoma. All 5 DLBCL cases were treated with CHOP chemotherapy, and rituximab was given to 3 patients. Of the primary cutaneous follicle center lymphomas, 1 patient with stage II disease was treated with CHOP and is alive without recurrence for the past 5 years, whereas the other patient is on observation alone. The patient with precursor B-lymphoblastic lymphoma was started on MCP-841 protocol; however, the patient did not complete the treatment and died after 11 months.<bold>Conclusions: </bold>PCBCL is a heterogeneous group of diseases and dividing them into subtypes, based on morphology and immunophenotype, has therapeutic implications.
- Subjects
SKIN diseases; LYMPHOMAS; PATIENTS; HISTOLOGY; B cells; B cell lymphoma; SKIN tumors; RETROSPECTIVE studies
- Publication
Indian Journal of Cancer, 2018, Vol 55, Issue 2, p134
- ISSN
0019-509X
- Publication type
journal article
- DOI
10.4103/ijc.IJC_418_17